GSM2310884[Accession] - GEO DataSets

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Items: 4

Select item 2000983501.

Epigenetic identity in AML is mostly dependent on disruption of non-promoter regulatory elements and reveals potentially antagonistic effects of mutations in epigenetic modifiers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Third-party reanalysis; Methylation profiling by high throughput sequencing

Platform:: GPL11154
126 Samples

Download data: TXT

Series

Accession:: GSE98350

ID:: 200098350

PubMed Full text in PMC Similar studies

Select item 2000869522.

Epigenetic identity in AML is mostly dependent on disruption of non-promoter regulatory elements and reveals potentially antagonistic effects of mutations in epigenetic modifiers [human]

(Submitter supplied) Aberrant DNA methylation of gene promoters is a hallmark of AML. To define how cytosine methylation is redistributed in AML more precisely we performed base-pair resolution methylome sequencing in 119 patients. We find that leukemic DNA methylation patterning is tightly linked to somatic mutations and primarily driven by regulatory elements outside of promoters and by CpG shores as opposed to CpG islands. more...