GEO DataSets

(Submitter supplied) The activation of vascular smooth muscle cells (VSMCs) during hypertension-induced arterial remodeling processes relies on a change of the gene expression program, i.e., up-regulation of genes to induce migration, proliferation and matrix degradation/synthesis. At the same time, genes controlling the quiescent, contractile VSMC phenotype are down-regulated. We used microarrays to detail the global program of gene expression underlying hypertension-induced vascular remodeling in the presence and absence of regulator of G-protein signaling 5 (RGS5) and identified distinct classes of down-regulated genes during vascular remodeling when RGS5 was not present.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL22598

12 Samples

Download data: CEL

(Submitter supplied) This Platform is identical to GPL16570 but a custom CDF environment was used to extract data [Brainarray Version 20, mogene20st]. The CDF file can be downloaded using the supplementary file link at the bottom of this record; the CDF and other files can be downloaded at: http://brainarray.mbni.med.umich.edu/Brainarray/Database/CustomCDF/20.0.0/entrezg.asp Protocol: See manufacturer's website (www.affymetrix.com).

Organism:

Mus musculus

13 Series

1 Related Platform

118 Samples

Download data: CDF