GSM2641241[Accession] - GEO DataSets

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Items: 4

Select item 2000993401.

Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL19184 GPL19109
413 Samples

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Accession:: GSE99340

ID:: 200099340

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Select item 2000993252.

Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts [Tub-FE]

(Submitter supplied) Accumulating evidence suggests that dysregulation of hypoxia-regulated transcriptional mechanisms is involved in development of chronic kidney diseases (CKD). However, it remains unclear how hypoxia-induced transcription factors (HIFs) and subsequent biological processes contribute to CKD development and progression. In our study, genome-wide expression profiles of more than 200 renal biopsies from patients with different CKD stages revealed significant correlation of HIF-target genes with eGFR in glomeruli and tubulointerstitium. more...