GSM2897251[Accession] - GEO DataSets

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Items: 4

Select item 2001083901.

Systematic functional characterization of BAF mutations yields novel intra-complex synthetic lethalities

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
162 Samples

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Accession:: GSE108390

ID:: 200108390

PubMed Full text in PMC Similar studies

Select item 2001083882.

Systematic functional characterization of BAF mutations yields novel intra-complex synthetic lethalities [RNA-Seq]

(Submitter supplied) Aberrations in genes coding for subunits of the BAF chromatin remodeling complex are highly abundant in human cancers. Currently, it is not understood how these loss-of-function mutations contribute to cancer development and how they can be targeted therapeutically. The cancer type specific occurrence patterns of certain subunit mutations suggest subunit-specific effects on BAF complex function, possibly by the formation of aberrant residual complexes. more...