GSM3039862[Accession] - GEO DataSets - NCBI

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Items: 3

Select item 2001117961.

Nuclear Receptor NR2F6 as an Alternative Cancer Immune Checkpoint in the T Cell Compartment

(Submitter supplied) Analyzing mouse tumor models in vivo, human T cells ex vivo and human lung cancer samples, we provide direct evidence that NR2F6 acts as novel immune checkpoint. Genetic ablation of Nr2f6, particularly in combination with blockade of the established PD-L1 cancer immune checkpoint, efficiently delayed tumor progression and improved survival in experimental mouse models. The target genes deregulated in intratumoral T lymphocytes upon genetic ablation of Nr2f6 alone or together with PD-L1 blockade, revealed multiple advantageous transcriptional alterations for effective tumor rejection. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18635
18 Samples

Download data: TXT

Series

Accession:: GSE111796

ID:: 200111796

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000186352.

Ion Torrent Proton (Mus musculus)

Organism:: Mus musculus

283 Series
3093 Samples

Platform

Accession:: GPL18635

ID:: 100018635

Select item 3030398623.

rep1_wt_IgG2b [Lexogen_34]

Organism:: Mus musculus

Source name:: Tumour infiltrating lymphocytes

Platform:: GPL18635
Series:: GSE111796

Sample

Accession:: GSM3039862

ID:: 303039862

SRA Run Selector

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