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Items: 3

1.

Nuclear Receptor NR2F6 as an Alternative Cancer Immune Checkpoint in the T Cell Compartment

(Submitter supplied) Analyzing mouse tumor models in vivo, human T cells ex vivo and human lung cancer samples, we provide direct evidence that NR2F6 acts as novel immune checkpoint. Genetic ablation of Nr2f6, particularly in combination with blockade of the established PD-L1 cancer immune checkpoint, efficiently delayed tumor progression and improved survival in experimental mouse models. The target genes deregulated in intratumoral T lymphocytes upon genetic ablation of Nr2f6 alone or together with PD-L1 blockade, revealed multiple advantageous transcriptional alterations for effective tumor rejection. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18635
18 Samples
Download data: TXT
Series
Accession:
GSE111796
ID:
200111796
2.

Ion Torrent Proton (Mus musculus)

Platform
Accession:
GPL18635
ID:
100018635
3.

rep4_Nr2f6_aPDL1 [Lexogen_43]

Organism:
Mus musculus
Source name:
Tumour infiltrating lymphocytes
Platform:
GPL18635
Series:
GSE111796
Download data
Sample
Accession:
GSM3039868
ID:
303039868
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Supplemental Content

db=gds|term=GSM3039868[Accession]|query=1|qty=2|blobid=MCID_6691e28e097f45704753f7bb|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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