GSM3084598[Accession] - GEO DataSets

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Items: 4

Select item 2001128351.

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL21273
91 Samples

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Accession:: GSE112835

ID:: 200112835

PubMed Similar studies

Select item 2001128322.

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [RNA-seq]

(Submitter supplied) The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. Deficiency in Setd2 leads to extensive alterations of the oocyte epigenome, including the loss of H3K36me3, failure in establishing the correct DNA methylome, invasion of H3K4me3 and H3K27me3 into former H3K36me3 territories and aberrant acquisition of H3K4me3 at imprinting control regions instead of DNA methylation. more...