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Items: 4

1.

Aging alters the epigenetic asymmetry of HSC division

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL21493
341 Samples
Download data: BED
Series
Accession:
GSE116712
ID:
200116712
2.

Aging alters the epigenetic asymmetry of HSC division [scATAC-Seq]

(Submitter supplied) Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase Cdc42. Here we demonstrate, using a comprehensive set of paired daughter cell analyses that include single cell 3D-confocal imaging, single cell transplants, single cell RNA-seq as well as single cell ATAC-seq, that the outcome of HSC divisions is strongly linked to the polarity status before mitosis, which is in turn determined by the level of the activity Cdc42 in stem cells. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
48 Samples
Download data: BED
Series
Accession:
GSE116707
ID:
200116707
3.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
4.

Young_Daughter 3y4A

Organism:
Mus musculus
Source name:
LT-HSC sorted from young mouse (daughter cell)
Platform:
GPL21493
Series:
GSE116707 GSE116712
Download data: BED
Sample
Accession:
GSM3258892
ID:
303258892
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Supplemental Content

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