GSM3417789[Accession] - GEO DataSets

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Items: 4

Select item 2001208871.

Inherent DNA binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL20301
84 Samples

Download data: BED, BIGWIG, TXT

Series

Accession:: GSE120887

ID:: 200120887

PubMed Full text in PMC Similar studies

Select item 2001208852.

Inherent DNA binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin (ChIP-seq)

(Submitter supplied) Hypoxia inducible factor (HIF) is the major transcriptional regulator of cellular responses to hypoxia. The two principal HIF-a isoforms, HIF-1a and HIF-2a, are progressively stabilized in response to hypoxia and form heterodimers with HIF-1b to activate a broad range of transcriptional responses. Here we report on the pan-genomic distribution of isoform-specific HIF binding in response to hypoxia of varying severity and duration, and in response to genetic ablation of each HIF-a isoform. more...