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Items: 4

1.

Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

(Submitter supplied) CD3-positive T cells were negatively isolated from 10 SLE patients and 9 healthy controls without SLE. All of the SLE samples and control samples were compared with one another to identify baseline differences in expression due to the disease. Next, T cell preparations from 4 of the control subjects were stimulated with either Nitric Oxide (NOC-18) 600 uM for 24hr or stimulated through CD3/CD28 for 24hr to determine which genes were responsive to these signaling mechanisms. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4188 GDS4719
Platform:
GPL570
27 Samples
Download data: CEL, CHP
Series
Accession:
GSE13887
ID:
200013887
2.
Full record GDS4719

Systemic lupus erythematosus CD3+ T cells

Analysis of CD3-positive T cells isolated from 10 systemic lupus erythematosus (SLE) patients and 9 healthy controls. SLE is an autoimmune disease characterized by T cell dysfunction. Results provide insight into molecular mechanisms underlying SLE in T cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE13887
19 Samples
Download data: CEL, CHP
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5669 Series
61 Related Platforms
174579 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

BC5 TC

Organism:
Homo sapiens
Source name:
T cells
Platform:
GPL570
Series:
GSE13887
Dataset:
GDS4719
Download data: CEL, CHP
Sample
Accession:
GSM349742
ID:
300349742
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