GSM3630117[Accession] - GEO DataSets

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Items: 4

Select item 2001271961.

Topological isolation as a mechanism for precise control of developmental regulators in mammalian genomes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL20301
81 Samples

Download data: BEDGRAPH, H5, TXT

Series

Accession:: GSE127196

ID:: 200127196

PubMed Full text in PMC Similar studies

Select item 2001271942.

Topological isolation as a mechanism for precise control of developmental regulators in mammalian genomes [RNA-seq]

(Submitter supplied) Recent investigation of insulated chromosome structures suggests their crucial role in controlling proper gene expression. However, it remains unclear whether developmental regulators can be precisely controlled by such insulated structures and whether developmental failure is caused by disrupting the structure boundaries. Here we identified topologically insulated regions (TIRs) from deeply sequenced human embryonic stem cell (hESC) Hi-C data and analyzed the gene distribution across TIRs. more...