GSM4216373[Accession] - GEO DataSets

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Items: 4

Select item 2001419261.

Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL21103
14 Samples

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Series

Accession:: GSE141926

ID:: 200141926

PubMed Full text in PMC Similar studies

Select item 2001419242.

Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out pups (P6) as compared to wild type controls

(Submitter supplied) To explore the mechanisms through which GLUT1 controls EC function, we compared transcriptomic alterations induced by loss of GLUT1 by performing RNA sequencing analysis on freshly isolated ECs from P6 GLUT1EC-/- brains. At P6, 447 genes were differentially expressed between WT and GLUT1-/- ECs. Subsequent gene set enrichment analysis showed that within the most differentially expressed pathways, several ones were related to p53, as well as inflammatory related pathways.