GEO DataSets

(Submitter supplied) We report single-cell RNA sequencing datasets for three lymphoblastoid cell lines (LCLs) prepared by infection of primary B cells with Epstein-Barr Virus (EBV). Inter- and intra-sample transcriptional variance is observed with respect to immunoglobulin heavy chain class; host gene sets involved in survival, proliferation and differentiation; and viral replication state. We propose that the observed heterogeneity arises from the dynamic nature of host-pathogen interactions, donor-specific compositions of primary B cells, and other experimental factors such as stochastic clonal evolution in cell culture conditions.

Organism:

Homo sapiens; human gammaherpesvirus 4

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23362

3 Samples

Download data: MTX, TSV