(Submitter supplied) Three-dimensional genome architecture influences the regulation of essential nuclear processes, such as gene transcription. However, how 3D genome architecture is affected by evolutionary forces within major lineages remains unclear. Here, we report a comprehensive comparison of 3D genomes, using high resolution Hi-C data in fibroblast cells of fish, chickens, and 10 mammalian species. This analysis shows a correlation between genome size and chromosome length that affects chromosomal territory (CT) organization in the upper hierarchy of genome architecture, whereas lower hierarchical features, including local transcriptional availability of DNA, are selected through vertebrate’s evolution.
more...- Organism:
- Homo sapiens; Mus musculus; Felis catus; Bos taurus; Ovis aries; Oryctolagus cuniculus; Rattus norvegicus; Canis lupus familiaris; Danio rerio; Gallus gallus; Macaca mulatta
- Type:
- Other
- 11 related Platforms
- 25 Samples
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