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Items: 4

1.

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia

(Submitter supplied) The NF-κB pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-κB response is regulated by the activation state of the IκB kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported that NF-κB is downstream of Notch1 in T cell acute lymphoblastic leukaemia (T-ALL), however both the mechanisms involving Notch1-induced NF-κB activation and the potential importance of NF-κB in the maintenance of the disease are unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4213
Platform:
GPL570
20 Samples
Download data: CEL
Series
Accession:
GSE20667
ID:
200020667

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.
Full record GDS4213

NF-kB inactivation effect on T-ALL1 cell lines

Analysis of T cell acute lymphoblastic leukemia (T-ALL) cell lines treated with a peptide that inhibits the activity of IKK, an activator of NF-kB. NF-kB pathway is downstream of oncogenic Notch1 in T-ALL. Results provide insight into the molecular basis of Notch-induced NF-kB activation in T-ALL.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 5 cell line sets
Platform:
GPL570
Series:
GSE20667
20 Samples
Download data: CEL
DataSet
Accession:
GDS4213
ID:
4213

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5669 Series
61 Related Platforms
174579 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570

4.

KOPT-K control 1

Organism:
Homo sapiens
Source name:
control peptide-treated KOPT-K 100mM 16h
Platform:
GPL570
Series:
GSE20667
Dataset:
GDS4213
Download data: CEL
Sample
Accession:
GSM542397
ID:
300542397

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