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Items: 3

1.

Epithelial XBP1 coordinates TP53-driven DNA damage responses and suppression of intestinal carcinogenesis

(Submitter supplied) We assessed the impact of intestinal epithelial XBP1 in coordinating epithelial DNA damage responses. As our data revealed that low XBP1 activity in the context of chronic DNA damage is associated with both reduced p53 pathway activity and formation of tumors with metastaic potential in-vivo, we performed RNA sequencing of intestinal organoids (H2b/Xbp1fl/fl, H2bΔIEC, H2b/Xbp1ΔIEC, H2b/p53∆IEC) to identify a transcriptional program downstream of p53 that drives the tumorigenic in-vivo phenotype.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
15 Samples
Download data: TXT
Series
Accession:
GSE182353
ID:
200182353

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 4000 (Mus musculus)

Organism:
Mus musculus
6575 Series
141245 Samples
Download data
Platform
Accession:
GPL21103
ID:
100021103

3.

LW50 Xbp1KO C

Organism:
Mus musculus
Source name:
Intestinal organoid
Platform:
GPL21103
Series:
GSE182353
Download data: TXT
Sample
Accession:
GSM5527492
ID:
305527492

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db=gds|term=GSM5527492[Accession]|query=3|qty=2|blobid=MCID_67239571aac997759733287b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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