GSM5603737[Accession] - GEO DataSets

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Items: 4

Select item 2001850381.

Human Pluripotent Stem Cell-derived Islets Ameliorate Diabetes in Nonhuman Primates

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca mulatta; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24522 GPL20795
19 Samples

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Series

Accession:: GSE185038

ID:: 200185038

PubMed Similar studies

Select item 2001850352.

Human Pluripotent Stem Cell-derived Islets Ameliorate Diabetes in Nonhuman Primates [human_bulk]

(Submitter supplied) Human pluripotent stem cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment. Here, we demonstrate that transplantation of human pluripotent stem cell-derived islets into diabetic nonhuman primates effectively restored endogenous insulin secretion and improved glycemic control. Single-cell RNA sequencing analysis of S6D2 clusters confirmed the existence of the three major pancreatic endocrine cell populations (β cells, α-like cells and δ-like cells) and their proportions, which altogether accounted for 80%. more...