GEO DataSets

(Submitter supplied) Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and cMyc) for short periods of time restores a youthful epigenetic signature to aging cells and extends the lifespan of a premature aging mouse model. However, the effects of longer-term partial reprogramming in physiologically aging wild-type mice are unknown. Here, we have performed various long-term partial reprogramming regimens, including different onset timings, during physiological aging in different mouse strains. more...

Organism:

Rattus norvegicus; Homo sapiens; Mus musculus

Type:

Methylation profiling by array

Platform:

GPL28271

168 Samples

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(Submitter supplied) Developed in the labs of Steve Horvath and Jason Ernst. The mammalian array platform applies to ALL mammals (humans, mouse, rat, sheep, horses, pigs, etc.). The array design is similar to the Illumina Infinium 450K array but it contains fewer up to 37492 CpGs. Additional material can be found on the Github page https://github.com/shorvath/MammalianMethylationConsortium/ A vignette on using the mammal methylation array with SeSAMe is available from https://bioconductor.org/packages/release/bioc/vignettes/sesame/inst/doc/mammal.html. more...

Organism:

Homo sapiens; Mus musculus; Rattus norvegicus

47 Series

22261 Samples

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