GSM586735[Accession] - GEO DataSets

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Items: 3

Select item 2000237721.

Why does HAMLET preferentially kill tumor cells? p38-dependent death in tumor but up-regulation of innate immunity in healthy, differentiated cells

(Submitter supplied) HAMLET triggers a p38- and ER stress-dependent death response in carcinoma cells. Transcriptome and proteome analysis detected an increase in p38 expression and phosphorylation exclusively in carcinoma cells and p38 inhibitors delayed the death response to HAMLET in carcinoma and lymphoma cells. ER stress gene expression was also increased in tumor cells and HAMLET triggered rapid XBP1 mRNA splicing, eIF2a phosphorylation, and ATF6 cleavage as well as Hsc70 and CHOP activation, suggesting that ER stress caused by HAMLET may trigger p38 phosphorylation and death. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
78 Samples

Download data: TXT

Series

Accession:: GSE23772

ID:: 200023772

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000068842.

Illumina HumanWG-6 v3.0 expression beadchip

(Submitter supplied) The HumanWG-6 v3.0 Expression BeadChip features up-to-date content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36.2, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. These should be submitted as part of a GEOarchive. more...