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Items: 3

1.

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

(Submitter supplied) Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2 hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large AML patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a specific hypermethylation signature. Furthermore, expression of 2HG-producing IDH alleles in cells rapidly induced global DNA hypermethylation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Methylation profiling by genome tiling array
Platforms:
GPL6602 GPL6604
757 Samples
Download data: PAIR, TXT
Series
Accession:
GSE24505
ID:
200024505

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

HG17_Human_60mer_1in2

(Submitter supplied) See Roche NimbleGen website
Organism:
Homo sapiens
11 Series
504 Samples
Download data: NDF, NGD
Platform
Accession:
GPL6602
ID:
100006602

3.

AML_GE_158

Organism:
Homo sapiens
Source name:
AML blast cells
Platform:
GPL6602
Series:
GSE24505
Download data: PAIR
Sample
Accession:
GSM603839
ID:
300603839

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db=gds|term=GSM603839[Accession]|query=3|qty=2|blobid=MCID_6736681826808c4a204e6fcb|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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