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Items: 4

1.

N6-methyladenosine-enhanced FZR1 translation contributes to gemcitabine insensitivity in pancreatic cancer via quiescence maintenance [m6A-seq]

(Submitter supplied) Herein, by detecting the global m6A profile in a panel of gemcitabine-sensitive and gemcitabine-insensitive PDAC cells, we identified the key role of hyper-m6A modification of the master G0/G1 regulator Fizzy and Cell Division Cycle 20 Related 1 (FZR1) in regulating gemcitabine sensitivity. Targeting m6A modification of FZR1 improves the gemcitabine treatment response of gemcitabine-insensitive PDAC cells in vitro and in vivo. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL20795
12 Samples
Download data: NARROWPEAK
Series
Accession:
GSE206968
ID:
200206968

Analyze with GEO2R

2.

N6-methyladenosine modification of FZR1 mRNA promotes gemcitabine resistance in pancreatic cancer

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer with limited therapeutic options, and gemcitabine insensitivity remains a major challenge. N6-methyladenosine (m6A) is a prevalent nucleotide modification in mRNA that has been linked to various biological processes in human diseases, yet its role in drug sensitivity of cancer remains largely unknown. Herein, by detecting the global m6A profile in a panel of gemcitabine-sensitive and gemcitabine-insensitive PDAC cells, we identified the key role of hyper-m6A modification of the master G0/G1 regulator Fizzy and Cell Division Cycle 20 Related 1 (FZR1) in regulating gemcitabine sensitivity. more...
Organism:
Homo sapiens
Type:
Other; Methylation profiling by high throughput sequencing
Platforms:
GPL20301 GPL20795
15 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE206969
ID:
200206969

3.

HiSeq X Ten (Homo sapiens)

Organism:
Homo sapiens
2048 Series
35295 Samples
Download data
Platform
Accession:
GPL20795
ID:
100020795

4.

HPAF-II, GEM-INS, IP

Organism:
Homo sapiens
Source name:
HPAF-II
Platform:
GPL20795
Series:
GSE206968 GSE206969
Download data: NARROWPEAK
Sample
Accession:
GSM6267433
ID:
306267433

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db=gds|term=GSM6267433[Accession]|query=10|qty=2|blobid=MCID_670f6a22c7d3ca20d52e3fd4|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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