GEO DataSets

(Submitter supplied) Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopically in heterologous cells. Herein, we screened the key molecular factors governing the dopaminergic neuronal specification during brain development for their ability to generate similar neurons directly from mouse and human fibroblasts. Remarkably, we found a minimal set of three factors Mash1, Nurr1 and Lmx1a/b able to elicit such cellular reprogramming. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4155

Platform:

GPL6246

8 Samples

Download data: CEL

Analysis of induced dopaminergic (iDA) neurons generated from E14.5 mouse embryonic fibroblasts (MEFs) reprogrammed by infection with lentiviruses expressing dopaminergic transcription factors Ascl1, Lmx1a and Nurr1. Results provide insight into the molecular basis of MEF to iDA reprogramming.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE27174

8 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2496 Series

28 Related Platforms

30138 Samples

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