GSM712783[Accession] - GEO DataSets

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Items: 3

Select item 2000287871.

Interaction between endothelium and chronic lymphocytic leukemia B-cells rescues from apoptosis and modulates gene expression profile of leukemic cells

(Submitter supplied) Chronic lymphocytic leukemic B cells (CLL) reside in close contact with activated endothelial cells (EC) in infiltrated tissues. Here, we investigated the interactions between EC and CLL cells, highlighting molecular networks involved in this cellular crosstalk. We co-cultured purified CLL cells on HUVEC monolayer (HC) or in medium alone. We found that EC protected CLL from spontaneous apoptosis. A 2.2-fold increase in relative viability in IGHV mutated CLL and a 6.1-fold increase in IGHV unmutated CLL was detected in co-culture. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
27 Samples

Download data: TXT

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Accession:: GSE28787

ID:: 200028787

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000064802.

Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)

(Submitter supplied) This multi-pack (4X44K) formatted microarray represents a compiled view of the human genome as it is understood today. The sequence information used to design this product was derived from a broad survey of well known sources such as RefSeq, Goldenpath, Ensembl, Unigene and others. The resulting view of the human genome covers 41K unique genes and transcripts which have been verified and optimized by alignment to the human genome assembly and by Agilent's Empirical Validation process. more...