GSM7141022[Accession] - GEO DataSets

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Items: 4

Select item 2002288801.

RIF1 regulates early replication timing in murine B cells.

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating murine B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin and promotes early replication, but plays a minor role in regulating replication origin activity, gene expression and genome organization in B cells. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

4 related Platforms
69 Samples

Download data: BEDGRAPH, BW, HIC, MCOOL

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Accession:: GSE228880

ID:: 200228880

PubMed Full text in PMC Similar studies

Select item 2002288782.

RIF1 regulates replication origin activity and early replication timing in B cells [Repli-Seq]

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin, regulates early origin firing and promotes early replication. more...