GSM7439806[Accession] - GEO DataSets

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Items: 4

Select item 2002339581.

Basis of gene-specific transcription regulation by the Inegrator Complex

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL34284 GPL24676
63 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE233958

ID:: 200233958

Select item 2002339572.

Basis of gene-specific transcription regulation by the Inegrator Complex (RNA-Seq)

(Submitter supplied) Integrator (INT) is a multi-subunit modular RNA processing complex, which exhibits both RNA endonuclease and protein phosphatase activity. It is responsible for transcription termination at the 3’ ends of a diverse array of RNA polymerase II (RNAP2) transcribed non-coding RNAs, as well as transcription regulation at a large number of protein coding genes. There, it terminates RNAP2 at promoter proximal pausing sites, cleaves the nascent transcript and competes with elongation factors.This INT-mediated tapering of gene expression attenuates stimulus responsive genes and is essential for cell differentiation. more...