GSM7458227[Accession] - GEO DataSets

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Items: 4

Select item 2002342951.

Systematic assessment of ISWI subunits reveals that NURF creates local accessibility for CTCF

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing

4 related Platforms
124 Samples

Download data: MCOOL, WIG

Series

Accession:: GSE234295

ID:: 200234295

Select item 2002342512.

Systematic assessment of ISWI subunits reveals that NURF creates local accessibility for CTCF [Mnase-seq]

(Submitter supplied) Catalytic activity of the ISWI family of remodelers is critical for nucleosomal organization and transcription factor binding, including the insulator protein CTCF. To define which subcomplex mediate these diverse functions we phenotyped a panel of isogenic mouse stem cell lines each lacking one of six ISWI accessory subunits. Individual deletions of either CERF, RSF1, ACF, WICH or NoRC subcomplexes cause only moderate effects on the chromatin landscape, while removal of the NURF specific subunit BPTF leads to drastic reduction in chromatin accessibility and Snf2h ATPase localization around CTCF sites. more...