GSM7635081[Accession] - GEO DataSets

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Items: 4

Select item 2002376431.

Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2- dependent transcription of Ifng

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

Platform:: GPL24247
58 Samples

Download data: BW, H5, NARROWPEAK

Series

Accession:: GSE237643

ID:: 200237643

PubMed Similar studies

Select item 2002376412.

The transcriptional landscape associated with the deletion of Regnase-1 [RNA-Seq]

(Submitter supplied) Having identified the crucial role of IFN-γ in anti-tumor immunity of Reg-1ΔNK, we attempted to elucidate the mechanism underlying the regulation of Ifng in the context of Regnase-1 deletion. Despite the notable increase in Ifng mRNA expression in Reg-1ΔNK-NK cells, Ifng was not a direct substrate of Regnase-1. However, the production of the IFN-γ was further enhanced upon stimulation with IL-12/18. more...