GSM7666373[Accession] - GEO DataSets

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Items: 4

Select item 2002395051.

Bacterial single cell RNA-seq unveils cyclic-di-GMP as an antitoxin critical for antibiotic tolerance in biofilm.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Staphylococcus aureus; Pseudomonas aeruginosa PAO1; Escherichia coli str. K-12 substr. MG1655

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL27158 GPL26592 GPL28916
21 Samples

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Accession:: GSE239505

ID:: 200239505

Select item 2002395042.

Bacterial single cell RNA-seq unveils cyclic-di-GMP as an antitoxin critical for antibiotic tolerance in biofilm [scRNA-seq]

(Submitter supplied) Biofilms are heterogeneous bacterial communities featured by high persister prevalence, responsible for antibiotic tolerance. However, the mechanisms underlying persister formation within biofilms remained ambiguous. Here, by developing and utilizing a ribosomal RNA depleted bacterial single-cell RNA-seq method, RiboD-mSPLiT, we resolved biofilm heterogeneity and discovered pdeI as a marker gene for persister subgroup within biofilms. more...