GEO DataSets

(Submitter supplied) Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients, and used a genome-wide approach to identify 45 genes differentially expressed in ALL exhibiting cross-resistance to prednisolone, vincristine, asparaginase and daunorubicin. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

129 Samples

Download data: CEL

(Submitter supplied) primary ALL cells (B-lineage) sensitive to vincristine by the MTT in vitro sensitivity assay Keywords = ALL Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

75 Samples

Download data: CEL

(Submitter supplied) primary ALL cells (B-lineage) resistant to L-asparaginase by the MTT in vitro sensitivity assay Keywords = ALL Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

40 Samples

Download data: CEL

(Submitter supplied) primary ALL cells (B- and T-lineage) sensitive to vincristine by the MTT in vitro sensitivity assay Keywords = ALL Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

89 Samples

Download data: CEL

(Submitter supplied) primary ALL cells (B- and T-lineage) resistant to L-asparaginase by the MTT in vitro sensitivity assay Keywords = ALL Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

45 Samples

Download data: CEL

(Submitter supplied) Cellular drug resistance is associated with an unfavorable prognosis in pediatric acute lymphoblastic leukemia (ALL). To identify genes conferring resistance to antileukemic agents, we analyzed the expression of >12,700 genes in sensitive and resistant ALL cells obtained at diagnosis from 174 patients. This revealed 42, 59, 54 and 22 genes (P≤0.001) that were differentially expressed in B-lineage ALL that was sensitive versus resistant to prednisolone, vincristine, asparaginase or daunorubicin, respectively, with prediction accuracies of 71-76%. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

173 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...

Organism:

Homo sapiens

364 DataSets

1125 Series

11 Related Platforms

42429 Samples

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