(Submitter supplied) Diffuse infiltrating gliomas are the most common primary brain malignancy found in adults, and Glioblastoma multiforme, the highest grade glioma, is associated with a median survival of 7 months. Transcriptional profiling has been applied to 85 gliomas from 74 patients to elucidate glioma biology, prognosticate survival, and define tumor sub-classes. These studies reveal that transcriptional profiling of gliomas is more accurate at predicting survival than traditional pathologic grading, and that gliomas characteristically express coordinately regulated genes of one of four molecular signatures: neurogenesis, synaptic transmission, mitotic, or extra-cellular matrix.
more...- Organism:
- Homo sapiens
- Type:
- Expression profiling by array
- Datasets:
-
GDS1975
GDS1976
- Platforms:
- GPL97 GPL96
- 170 Samples
Download data: CEL, TXT