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Items: 1 to 20 of 89

1.

Deep learning-guided discovery of a narrow-spectrum antibiotic against Acinetobacter baumannii

(Submitter supplied) Acinetobacter baumannii is a nosocomial Gram-negative pathogen that often displays multidrug-resistance due to its robust outer membrane and its ability to acquire and retain extracellular DNA. Moreover, it can survive for prolonged durations on surfaces and is resistant to desiccation. Discovering new antibiotics against A. baumannii has proven challenging through conventional screening approaches. more...
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33052
7 Samples
Download data: CSV, TSV
Series
Accession:
GSE214305
ID:
200214305
2.

Acinetobacter baumannii ATCC 17978 Transcriptome Sequencing 37ºC Light/Dark

(Submitter supplied) We performed RNA sequencing analysis with differential expression analysis to compare the expression of genes between A. baumannii 17978 wildtype strain grown in the light and the dark. The purpose was to determine any genes whose expression was mediated by light at 37ºC, a temperature at which the currently best studied photoreceptor for A. baumannii BlsA, is unfunctional.
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL31244
6 Samples
Download data: TXT
Series
Accession:
GSE193924
ID:
200193924
3.

RNA-seq of Acinetobacter baumannii ATCC 17978: deleted effects of dna adenine methylase

(Submitter supplied) Comparison for gene expression of Acinetobacter baumannii ATCC 17978 by deleted effects of dna adenine methylase
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL31244
2 Samples
Download data: XLSX
Series
Accession:
GSE195621
ID:
200195621
4.

The abaI/abaR quorum sensing system effects pathogenicity in Acinetobacter baumannii

(Submitter supplied) Acinetobacter baumannii is a Gram-negative pathogen that has emerged as one of the most troublesome pathogens for health care institutions globally. Bacterial quorum sensing (QS) is a process of cell-to-cell communication that relies on the production, secretion and detection of autoinducer (AI) signals to share information about cell density and regulate gene expression accordingly. The molecular and genetic basis of Acinetobacter baumannii virulence remains poorly understood. more...
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23922
12 Samples
Download data: TXT
Series
Accession:
GSE173396
ID:
200173396
5.

Transcriptome of Acinetobacter baumannii ATCC 17978 treated polymyxin B

(Submitter supplied) We report the trascriptomic information of wild type (Lab-WT) during the growth with or without 0.5 MIC of polymyxin B added LB (Luria-Bertani broth) media
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29516
2 Samples
Download data: XLSX
Series
Accession:
GSE163581
ID:
200163581
6.

Transcriptome study of Acinobacter baumannii ddrR mutants in the presence or absence of mitomycin C

(Submitter supplied) All RNA samples were isolated from the ddrR mutant strain of Acinobacter baumannii. The triplicates labeled “plus” have been subjected to mitomycin C (MMC) exposure (treated) and the triplicates labeled “minus” were not exposed to MMC (control). A comparison between treated and control samples to determine differential gene expression was performed.
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24102
6 Samples
Download data: TXT
Series
Accession:
GSE104741
ID:
200104741
7.

Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in Acinetobacter baumannii ATCC 17978

(Submitter supplied) The goal of this study was to assess the role of the AdeRS two component signal transduction system in Acinetobacter baumannii ATCC 17978 and its impact on the virulence potential of this bacterial organism. Specific gene deletion strains targeting the adeRS system were generated and compared to wildtype for a number of phenotypic in vitro assays as well as transcriptomic profiling via RNA-sequencing.
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23922
2 Samples
Download data: TXT
Series
Accession:
GSE102711
ID:
200102711
8.

Characterization of two Acinetobacter baumannii rifampin-spontaneous mutants lacking twitching motility

(Submitter supplied) Transcriptional profiling of A. baumannii ATCC 17978 comparing two spontaneous rpoB mutants (Rif5 and Rif 8) with the wild-type parental strain
Organism:
Acinetobacter baumannii; Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by array
Platform:
GPL16729
4 Samples
Download data: TXT
Series
Accession:
GSE73193
ID:
200073193
9.

Bile salts in Acinetobacter baumannii clinical strains with lack of AdeABC efflux pump

(Submitter supplied) Few are the studies that analyzed the molecular features implicated to the tolerance to bile salts by A.baumannii clinical strains. Interestingly, Ab421 GEIH-2010 strain (belonging to ST79/PFGE-HUI-1 clone constitute by isolates with lacking of the AdeABC efflux pump) and A.baumannii ∆adeB ATCC 17978 showed higher tolerance to bile salts by the expression of the glutamate/aspartate transporter as well as virulence factors (Type VI Secretion System, twitching motility and biofilm) associated to the activation of the Quorum Sensing system.
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by array
Platform:
GPL16729
15 Samples
Download data: TXT
Series
Accession:
GSE85264
ID:
200085264
10.

Regulation of biofilm formation, twitching motility, and virulence in Galleria mellonella by AdeN protein of Acinetobacter baumannii

(Submitter supplied) AdeN deletion mutant AB141 was studied for its effects on biofilm formation, twitching motility, and virulence using phenotypic methods, and the further global role of AdeN was further studied using a multiomics approach
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22492
4 Samples
Download data: TXT
Series
Accession:
GSE89504
ID:
200089504
11.

Multi-omics approach to study global changes in a triclosan mutant strain of Acinetobacter baumannii ATCC 17978.

(Submitter supplied) Acinetobacter baumannii AB042, a triclosan-resistant mutant, was examined for modulated gene expression using whole genome sequencing, transcriptomics, and proteomics in order to understand the mechanism of triclosan-resistance as well as its impact on A. Baumannii.
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22492
4 Samples
Download data: DIFF, TXT, XLSX
Series
Accession:
GSE87398
ID:
200087398
12.

A. baumannii Cells: 1/2MIC chloramphenicol (Cm) tretment vs. 1/2MIC 4-hydroxybenzaldehyde (HBA) treatment vs. 1/4MIC combination of Cm and HBA treatment vs. Ethanol treatment

(Submitter supplied) Transcriptional profiling of Acinetobacter baumannii ATCC17978 cells comparing each treated 1/2MIC Cm, 1/2MIC HBA and combination of 1/4MIC Cm and HBA cells with same volume of ethanol treated. Based on the gene expression, we analyzed results to confirm the relation between Cm and HBA to antibacterial synergism against A. baumannii. (Concentrations treated respectivly in all samples were adjusted to add same volume of Cm, HBA and combination)
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by array
Platform:
GPL19060
3 Samples
Download data: GPR
Series
Accession:
GSE67173
ID:
200067173
13.

A. baumannii Cells: oleanolic acid (OA) tretment vs. ethanol treatment (OA solvent)

(Submitter supplied) Transcriptional profiling of Acinetobacter baumannii ATCC17978 cells comparing treated ethanol cells with oleanolic acid treated. Based on the gene expression, we performed experiments to confirm the therapeutic effect and mechanism of OA in A. baumannii.
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by array
Platform:
GPL19060
1 Sample
Download data: GPR
Series
Accession:
GSE60239
ID:
200060239
14.

Characterization of A. baumannii Mitomycin C (MMC) response

(Submitter supplied) Transcriptional profiling of A. baumannii ATCC 17978 comparing treated-MMC cultures with non-MMC treated cultures
Organism:
Acinetobacter baumannii ATCC 17978
Type:
Expression profiling by array
Platform:
GPL16729
3 Samples
Download data: TXT
Series
Accession:
GSE44735
ID:
200044735
15.

Illumina HiSeq 3000 (Acinetobacter baumannii ATCC 17978)

Organism:
Acinetobacter baumannii ATCC 17978
1 Series
7 Samples
Download data
Platform
Accession:
GPL33052
ID:
100033052
16.

Illumina NovaSeq 6000 (Acinetobacter baumannii ATCC 17978)

Organism:
Acinetobacter baumannii ATCC 17978
2 Series
8 Samples
Download data
Platform
Accession:
GPL31244
ID:
100031244
17.

Illumina HiSeq 2500 (Acinetobacter baumannii ATCC 17978)

Organism:
Acinetobacter baumannii ATCC 17978
1 Series
2 Samples
Download data
Platform
Accession:
GPL29516
ID:
100029516
18.

Illumina NextSeq 500 (Acinetobacter baumannii ATCC 17978)

Organism:
Acinetobacter baumannii ATCC 17978
1 Series
6 Samples
Download data
Platform
Accession:
GPL24102
ID:
100024102
19.

Illumina HiSeq 2000 (Acinetobacter baumannii ATCC 17978)

Organism:
Acinetobacter baumannii ATCC 17978
2 Series
14 Samples
Download data
Platform
Accession:
GPL23922
ID:
100023922
20.

Illumina MiSeq (Acinetobacter baumannii ATCC 17978)

Organism:
Acinetobacter baumannii ATCC 17978
2 Series
8 Samples
Download data
Platform
Accession:
GPL22492
ID:
100022492

Supplemental Content

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