GEO DataSets

(Submitter supplied) The arylhydrocarbon receptor is a ligand inducible transcription factor. Known to control xenobiotic metabolizing enzymes, it also affects - depending on the cell type - numerous other genes, either directly or indirectly. With respect to the immune system, persistent activation leads to immunosuppression. We asked how the AhR is involved in Langerhans cells. These antigen presenting cells of the skin are responsible for allergies against chemicals (thus xenobiotic metabolism might be relevant) and a recently detected endogenous ligand, FICZ made by UVB radiation from tryptophane, is particularly abundant in the skin. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3575

Platform:

GPL339

4 Samples

Download data: CEL

Analysis of Langerhan cells (LCs) lacking the aryl hydrocarbon receptor (AhR). LCs are Ag-presenting cells of the epidermis. AhR is a ligand-activated transcription factor involved in low molecular mass chemical metabolism and cell differentiation. Results provide insight into the role of AhR in LC.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE13130

4 Samples

Download data: CEL