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SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing [CLIP-Seq]

(Submitter supplied) SIRT7 is an NAD+-dependent protein deacetylase with important roles in ribosome biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-rRNA and promotes rRNA synthesis. Here we show that SIRT7 is also associated with snoRNAs that are involved in pre-rRNA processing and rRNA maturation. Knockdown of SIRT7 impairs U3 snoRNA-dependent early cleavage steps that are necessary for generation of 18S rRNA. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL11154
3 Samples
Download data: XLSX
Series
Accession:
GSE76578
ID:
200076578

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

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