GEO DataSet Links for BioProject (Select 94469) - GEO DataSets

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Items: 2

Select item 2000045511.

experiment in midbrain primary cultures, enriched in dopaminergic neurons

(Submitter supplied) To identify novel Nurr1 target genes we have used microarrays strategies in rat midbrain primary cultures, enriched in dopaminergic neurons, by the action of basic fibroblast growth factor (bFGF, 20ng/ml) and Sonic hedgedog (SHH), following upregulation of Nurr1 expression by depolarization.To this aim we have treated the cultures after 9 days in vitro for 2h with high KCl and collected 30 min or 2 h after the end of depolarization (2h + 30 min or 2h + 2h). more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2774
Platform:: GPL341
12 Samples

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Accession:: GSE4551

ID:: 200004551

Select item 27742.

Transcription factor Nurr1 overexpression induced by depolarization effect on midbrain neurons in vitro

Analysis of cultured midbrain neurons enriched for dopaminergic neurons following Nurr1 overexpression induced by depolarization. Nurr1 is a transcription factor essential for the generation of midbrain dopaminergic neurons. Results provide insight into the molecular pathways regulated by Nurr1.