GEO DataSets

Analysis of progressive left ventricular hypertrophy (LVH) in spontaneously hypertensive (SHR) males at 12, 16, and 20 months of age. LVH impairs diastolic relaxation, which decreases cardiac output and leads to heart failure (HF). Provides insight into pathogenesis of hypertrophy and LV remodeling.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 age, 2 strain sets

Platform:

GPL85

Series:

GSE2116

23 Samples

Download data: CEL, EXP

(Submitter supplied) Left ventricular gene expression profiles from 12-, 16- and 20-months old spontaneously hypertensive rats (SHRs) were compared with left ventricular profiles seen in age-matched Wistar-Kyoto (WKY) rats by screening Affymetrix U34A arrays (there are 4 samples in each timepoint except 3 samples of 20-months old WKYs). Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1264

Platform:

GPL85

23 Samples

Download data: CEL, EXP

(Submitter supplied) Expression profiling of hearts from FVB males subjected to cardiac pressure overload by transverse aortic constriction (TAC). TAC performed on 8-10 weeks month old males and females. Hearts examined 30 weeks after surgery. Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2258

Platform:

GPL81

15 Samples

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Analysis of heart left ventricles (LVs) of animals with pressure overload LV hypertrophy (LVH) caused by transverse aortic constriction. Pressure overload on the heart resulting from chronic hypertension or aortic stenosis is a stimulus for LVH. Results provide insight into the pathogenesis of LVH.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 gender sets

Platform:

GPL81

Series:

GSE2459

15 Samples

Download data

(Submitter supplied) Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild type (WT) controls. After 14 d of isoproterenol infusion cardiac hypertrophy in WT and myo-/- mice reached a similar level. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8600

16 Samples

Download data: GPR

(Submitter supplied) Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild type (WT) controls. After 14 d of isoproterenol infusion cardiac hypertrophy in WT and myo-/- mice reached a similar level. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8599

16 Samples

Download data: GPR

(Submitter supplied) Reactivation of fetal gene expression patterns has been demonstrated to play a crucial role in common cardiac diseases in adult life including left ventricular (LV) hypertrophy (LVH). Thus, increased wall stress and neurohumoral activation are discussed to induce the return to expression of fetal genes after birth in LVH. We therefore aimed to test whether fetal gene expression programs are linked to the genetic predisposition to LVH. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

26 Samples

Download data: TXT

(Submitter supplied) Numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac function. We have recently demonstrated that several of these can be "rescued" or prevented by transgenic cardiac expression of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARKct). To uncover genomic changes associated with cardiomyopathy and/or its phenotypic rescue by the betaARKct, oligonucleotide microarray analysis of left ventricular (LV) gene expression was performed in a total of 53 samples, including 12 each of Normal, HF, and Rescue. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS411 GDS427

Platforms:

GPL75 GPL76

106 Samples

Download data

Analysis of left ventricular (LV) gene expression to uncover genomic changes associated with cardiomyopathy and/or its phenotypic rescue by the beta-adrenergic receptor kinase, betaARKc.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 disease state sets

Platform:

GPL76

Series:

GSE670

53 Samples

Download data

Analysis of left ventricular (LV) gene expression to uncover genomic changes associated with cardiomyopathy and/or its phenotypic rescue by the beta-adrenergic receptor kinase, betaARKc.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 disease state sets

Platform:

GPL75

Series:

GSE670

53 Samples

Download data