Similar studies for GEO DataSets (Select 198) - GEO DataSets

(Submitter supplied) MHC-I overexpression in muscle biopsies is a hallmark of inflammatory myopathies.However the mechanisms of MHC-I overexpression in each disease is not well understood. Microarray analysis from MHC-I-microdissected myofibers showed a differential expression signature in each inflammatory myopathy. Innate immunity and IFN-I pathways are upregulated vs healthy controls, specifically in dermatomyositis (DM).

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4841
Platform:: GPL6244
19 Samples

Download data: CEL

Series

Accession:: GSE48280

ID:: 200048280

Select item 48414.

Inflammatory myopathies

Analysis of pathological skeletal muscle fibers from patients with dermatomyositis (DM), polymyositis (PM), or inclusion body myositis (IBM). Results provide insight into the molecular mechanisms underlying the pathogenesis of DM, PM, and IBM.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 disease state sets

Platform:: GPL6244
Series:: GSE48280
19 Samples

Download data: CEL

DataSet

Accession:: GDS4841

ID:: 4841

Select item 2000394545.

Genomic signatures characterize leukocyte infiltration in myositis muscles

(Submitter supplied) Immune cell infiltration in myositis were by examining microarray expression profiles in muscle biopsies from 31 myositis patients and 5 normal controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
36 Samples

Download data: CEL

Series

Accession:: GSE39454

ID:: 200039454

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000020446.

Combining gene expression data from different generations of oligonucleotide arrays

(Submitter supplied) Compatibility between high-density oligonucleotide arrays is significantly affected by probe-level sequence information. With a careful filtering of the probes based on their sequence overlaps, data from different generations of microarrays can be combined more effectively. The dataset of 14 human muscle biopsy samples from patients with inflammatory myopathies that were hybridized on both HG-U95Av2 and HG-U133A human arrays for this purpose. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL8300
28 Samples

Download data: CEL

Series

Accession:: GSE2044

ID:: 200002044

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000004937.

Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis

(Submitter supplied) Juvenile dermatomyositis (JDM), the most common pediatric inflammatory myopathy, is a systemic vasculopathy affecting young children. Epidemiology studies documenting an antecedent illness in the 3 mo before the first definite symptom (rash and/or weakness) of JDM are supported by immunologic data that suggest that the disease pathophysiology is Ag driven. The purpose of this study was to compare the gene expression profiles in muscle biopsies of four untreated DQA1*0501(+) JDM children with profiles from children with a known necrotizing myopathy (Duchenne muscular dystrophy), as well as an in vitro antiviral model (NF90), and healthy pediatric controls. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS215 GDS258
Platforms:: GPL80 GPL246
14 Samples

Download data: CEL

Series

Accession:: GSE493

ID:: 200000493

Select item 2588.

Juvenile dermatomyositis muscle profile (HuGeneFL)

Examination of skeletal muscle from juvenile dermatomyositis (JDM) patients, a common pediatric inflammatory myopathy. Muscle biopsies processed singly or in mixed groups of two. Patients genotyped for TNFalpha which is associated with prolonged disease.