Similar studies for GEO DataSets (Select 200001138) - GEO DataSets

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Items: 20

Select item 2000011381.

Gene expression in mouse ovary and testis

(Submitter supplied) To investigate the genomic distribution of genes with sex- biased expression patterns in mice we analyzed the chromosomal distribution of genes preferentially expressed in sexually dimorphic tissues such as testis and ovary. Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL977
21 Samples

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Series

Accession:: GSE1138

ID:: 200001138

Select item 2000034362.

Gene expression profile in juvenile Spo11 knockout testes

(Submitter supplied) Spo11, a meiosis-specific protein, introduces double strand breaks on chromosomes and initiates meiotic recombination in a wide variety of organisms. Mouse null Spo11 spermatocytes fail to synapse chromosomes and to progress beyond zygotene stage of meiosis. We analyzed gene expression profiles in Spo11-/- adult and juvenile wild type testis to determine genes expressed in different stages of meiosis and spermatogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL977
9 Samples

Download data: GPR

Series

Accession:: GSE3436

ID:: 200003436

Select item 2000195323.

Screening of genes involved in chromosome segregation in meiosis I

(Submitter supplied) Prophase I of male meiosis involves dynamic chromosome segregation processes during early spermatogenesis, including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility in humans, we performed expression profiling of mouse spermatogenic cells undergoing meiotic prophase I.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL340 GPL339
10 Samples

Download data: CEL, CHP

Series

Accession:: GSE19532

ID:: 200019532

Select item 2000073064.

Chromosomal rearrangement interferes with meiotic X-chromosome inactivation

(Submitter supplied) Expression profiling of isolated populations of prepachytene spermatocytes, pachytene spermatocytes and spermatids of males carrying a translocation T(16;17)43H was performed to study the influence of this translocation on gene expression from individual chromosomes. To evaluate the transcriptional behavior of individual chromosomes in the sterile B10-T43/+ males and their fertile congenic B10-T43/T43 and B10 counterparts, we compared their transcriptomes in sorted populations of pre-pachytene primary spermatocytes, pachytene primary spermatocytes and spermatids. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5008
18 Samples

Download data: CEL

Series

Accession:: GSE7306

ID:: 200007306

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001757345.

Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice

(Submitter supplied) TAR DNA binding protein of 43 kDa (TDP-43; gene name: Tardbp), a ubiquitously expressed evolutionarily conserved protein, is highly expressed in the preleptotene and pachytene spermatocytes. TDP-43 is linked to several human neurodegenerative disorders. Exploring its functional requirement for spermatogenesis for the first time, we show here that conditional knockout (cKO) of Tardbp in male germ cells of mice leads to failure of meiosis and arrest of spermatogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: XLSX

Series

Accession:: GSE175734

ID:: 200175734

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000041936.

Gene expression in murine germ cells

(Submitter supplied) In mammals, the X and Y chromosomes are subject to meiotic sex chromosome inactivation (MSCI) during prophase I in the male germline, but their status thereafter is currently unclear. An abundance of X-linked spermatogenesis genes has spawned the view that the X must be active [1-8]. On the other hand, the idea that the imprinted paternal X of the early embryo may be pre-inactivated by MSCI suggests that silencing may persist longer [9-12]. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2390
Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE4193

ID:: 200004193

Select item 23907.

Male germ cells

Analysis of four spermatic subpopulations: type A and type B spermatogonia, pachytene spermatocytes, and round spermatids. The X and Y chromosomes are subject to meiotic sex chromosome inactivation in the mammalian male germline. Results provide insight into the extent of postmeiotic X silencing.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 cell type sets

Platform:: GPL1261
Series:: GSE4193
8 Samples

Download data: CEL

DataSet

Accession:: GDS2390

ID:: 2390

Select item 2000034138.

Dosage Compensation of the Active X in mammals

(Submitter supplied) Here, we show that doubling of the global expression level of the X chromosome achieves dosage compensation in somatic tissues from several mammalian species. X-linked genes are highly expressed in brain tissues, consistent with a role in cognitive functions. Keywords: Normal Tissue

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

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Series

Accession:: GSE3413

ID:: 200003413

Select item 2000017689.

Round Spermatids and Pachytene Spermatocytes

(Submitter supplied) Mouse Round Spermatids (Sptd) and Pachytene Spermatocytes (Spcy) Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL1451 GPL1452 GPL1450
9 Samples

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Series

Accession:: GSE1768

ID:: 200001768

Select item 20003573410.

Screening of genes involved in chromosome segregation in meiosis I

(Submitter supplied) Prophase I of meiosis involves dynamic chromosome segregation processes including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility or recurrent pregnancy loss in humans, we performed expression profiling of male and female gonads of mice undergoing meiotic prophase I.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4503
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE35734

ID:: 200035734

Select item 450311.

Gonadal development: ovaries and testes

Analysis of gonads from fetal, neonatal and adult C57BL/6 males and females. Events during meiosis I prophase are critical for correct segregation of chromosomes. Defects in these events may contribute to infertility. Results provide insight into molecular mechanisms underlying meiosis I prophase.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 age, 2 tissue sets

Platform:: GPL1261
Series:: GSE35734
6 Samples

Download data: CEL

DataSet

Accession:: GDS4503

ID:: 4503

Select item 20009692112.

Identification of YTHDC2 targets in mouse postnatal testis

(Submitter supplied) YTHDC2 targets in mouse P20 testis

Organism:: Mus musculus

Type:: Other

Platform:: GPL16417
6 Samples

Download data: TXT

Series

Accession:: GSE96921

ID:: 200096921

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009070213.

Identification of the embryonic germ cell Meioc-/- transcriptome, MEIOC targets in postnatal testis, and YTHDC2 targets in postnatal testis in mouse

(Submitter supplied) Identification of the embryonic germ cell Meioc-/- transcriptome, MEIOC targets in postnatal testis, and YTHDC2 targets in postnatal testis in mouse

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL16417 GPL13112
26 Samples

Download data: FPKM_TRACKING, TXT

Series

Accession:: GSE90702

ID:: 200090702

PubMed Full text in PMC Similar studies

Select item 20007283314.

Regulatory complexity revealed by integrated cytological and RNA-seq analyses of meiotic substages in mouse spermatocytes

(Submitter supplied) The juvenile onset of spermatogenesis in mice is analyzed by combining cytological and transcriptomic data in a novel computational analysis, resulting in meiotic substage-specific transcriptomes and the discovery of a transcription factor network that regulates the substages of meiosis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL13112
32 Samples

Download data: TXT, XLSX

Series

Accession:: GSE72833

ID:: 200072833

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009907615.

Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint

(Submitter supplied) To elucidate the molecular bases for the infertile phenotype of Zmym3 KO mice at the mRNA expression level, we carried out RNA sequencing (RNA-seq) analysis on cultured spermatogonial stem cells (SSCs), c-KIT+ pre-meiotic cells induced from SSCs and spermatocytes directly isolated from adult mouse testes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21273 GPL21103
12 Samples

Download data: XLSX

Series

Accession:: GSE99076

ID:: 200099076

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014034616.

Next Generation Sequencing Facilitates Quantitative Analysis of PHB-knockdown and PHB-knockout Spermatocytes Transcriptomes

(Submitter supplied) We analyzed the transcriptomic differences of cultured mouse spermatocytes (GC2 cells) stably transfected with PHB-targeting shRNA (called PHB KD GC2) from those with a control shRNA (called Ctrl GC2). Furthermore, we also analyzed the difference in the transcriptomes of spermatocytes between Phb conditional knock-out and control mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
12 Samples

Download data: TXT

Series

Accession:: GSE140346

ID:: 200140346

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000565517.

Comparison of pure-species Drosophila expression to hybrid expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster; Drosophila simulans x Drosophila mauritiana; Drosophila mauritiana; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:: Expression profiling by array

Platforms:: GPL4022 GPL3829
128 Samples

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Series

Accession:: GSE5655

ID:: 200005655

Select item 20000560718.

Comparison of D. simulans/D. sechellia F1 male hybrid genome-wide expression values to pure-species parents

(Submitter supplied) Species often produce sterile hybrids early in their evolutionary divergence, and some evidence suggests that hybrid sterility may be associated with deviations or disruptions in gene expression. In support of this idea, many studies have shown that a high proportion of male-biased genes are underexpressed compared to non-sex-biased genes in sterile F1 male hybrids of Drosophila species. In this study, we examined and compared patterns of misexpression in 4 day old sterile male F1 hybrids of Drosophila simulans and its sibling species, D. more...