GEO DataSets

(Submitter supplied) Comparative analysis of gene expression levels from hindlimb muscle tissue from 8 week old mouse models for muscular dystrophy. We have used mouse models with dystrophin-, sarcoglycan-, sarcospan-, or dysferlin-deficiency. Keywords = muscular dystrophy Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1770

26 Samples

Download data

(Submitter supplied) Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004. Keywords = microarray Keywords = muscle Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS638

Platform:

GPL81

36 Samples

Download data: CEL

Temporal analysis of diaphram muscle from dystrophin-deficient mdx mice, a Duchenne muscular dystrophy (DMD) model. Postnatal ages 7 to 112 days examined. Results provide insight into mechanisms of muscular dystrophy pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 age, 2 strain sets

Platform:

GPL81

Series:

GSE1026

36 Samples

Download data: CEL

(Submitter supplied) By comparing the transcriptome from proximal (quadriceps femoris, QF) and distal (tibialis anterior, TA)muscle groups in dysferlin deficient mouse muscle (the SJL mutation bred onto C57BL/10 to produces C57BL/10-SJL.Dysf) with proximal and distal muscle groups from control C57BL/10 mice of an equivalent age (3-weeks old, prior to the onset of overt pathology) we aim to address the issues of muscle selectivity in this this form of muscular dystrophy. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1233

Platform:

GPL81

12 Samples

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Comparison of the proximal quadriceps femoris muscle to the distal tibialis anterior muscle of 3 week old dysferlin deficient mutants. Dysferlin mutations can result in the neuromuscular disorders Limb-Girdle muscular dystrophy type 2B and Myoshi myopathy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL81

Series:

GSE2629

12 Samples

Download data

(Submitter supplied) Transcriptome analysis of hindlimb muscles from dystrophic mice Muscular dystrophies (MD) are a clinically and genetically heterogeneous group of mendelian diseases. The underlying pathophysiology and phenotypic variability in each form are much more complex, suggesting the involvement of many other genes. Thus, here we studied the whole genome expression profile in muscles from three mice models for MD, at different time points: Dmdmdx, carrying a mutation in dystrophin gene, Largemyd-/- with mutation in Large and Dmdmdx/Largemyd-/- bearing both mutations. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

60 Samples

Download data: CEL, CHP

(Submitter supplied) Dysferlin is expressed in skeletal and cardiac muscle. However, dysferlin deficiency, namely limb girdle muscular dystrophy 2B (LGMD2B) and Myoshi myopathy, results in skeletal muscle weakness and spares the heart. This dichotomy could be caused by differential regulation of protective mechanisms. Therefore, we compared intraindividual mRNA expression profiles between cardiac and skeletal muscle in dysferlin-deficient SJL/J mice and normal C57BL/6 mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1247

Platform:

GPL81

20 Samples

Download data: CEL, EXP, RPT

Comparison of skeletal and cardiac muscles of dysferlin deficient SJL/J animals. Dysferlin deficiency results in skeletal muscle weakness, but does not affect the heart. Dysferlin mutations can result in the neuromuscular disorders Limb-Girdle muscular dystrophy type 2B and Myoshi myopathy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL81

Series:

GSE2507

20 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) This is a large series human Duchenne muscular dystrophy patient muscle biopsies, in specific age groups, using all available Affymetrix arrays (including a custom MuscleChip produced by the Hoffman lab). Both mixed groups of patients (5 patient biopsies per group) and individual biopsies were done. Hypothesis: That the progression of DMD can be understood in terms of muscle molecular remodeling. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS214 GDS262 GDS264 GDS265 GDS270

7 related Platforms

57 Samples

Download data: CEL

Examination of muscle biopsies from Duchenne muscular dystrophy patients and normal subjects of various age groups. Both mixed groups of patients (5 patient biopsies per group) and individual biopsies analyzed.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 disease state sets

Platform:

GPL92

Series:

GSE465

4 Samples

Download data: CEL

Examination of muscle biopsies from Duchenne muscular dystrophy patients and normal subjects of various age groups. Both mixed groups of patients (5 patient biopsies per group) and individual biopsies analyzed.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 disease state sets

Platform:

GPL95

Series:

GSE465

5 Samples

Download data: CEL

Examination of muscle biopsies from Duchenne muscular dystrophy patients and normal subjects of various age groups. Both mixed groups of patients (5 patient biopsies per group) and individual biopsies analyzed.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 disease state sets

Platform:

GPL94

Series:

GSE465

5 Samples

Download data: CEL

Examination of muscle biopsies from Duchenne muscular dystrophy patients and normal subjects of various age groups. Both mixed groups of patients (5 patient biopsies per group) and individual biopsies analyzed.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 age, 2 disease state sets

Platform:

GPL91

Series:

GSE465

7 Samples

Download data: CEL

Examination of muscle biopsies from Duchenne muscular dystrophy patients and normal subjects of various age groups. Both mixed groups of patients (5 patient biopsies per group) and individual biopsies analyzed.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 age, 2 disease state sets

Platform:

GPL246

Series:

GSE465

30 Samples

Download data: CEL

(Submitter supplied) Transcript data from quadriceps skeletal muscle from fasted-state male BXD strains on Quadriceps, Chow or Quadriceps, High fat diet We used microarrays to compare the skeletal muscle expression differences across males in the BXD strain family and across two diverse diets

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

79 Samples

Download data: CEL, TXT

(Submitter supplied) We have performed expression profiling to define the molecular changes in dysferlinopathy using a novel dedicated microarray platform made with 3’-end skeletal muscle cDNAs. Eight dysferlinopathy patients, defined by western blot, immunohistochemistry and mutation analysis, were investigated with this technology. The expression profiles of patients with different clinical traits were independently obtained and hierarchical clustering was applied to discover patient-specific gene variations. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2677

10 Samples

Download data

(Submitter supplied) Human Array 1.0 was constructed arraying on glass slides PCR-amplified cDNAs obtained from our archive of recombinant bacterial clones. This archive consists of 2688 different cDNA clones collected after systematic sequencing of human skeletal muscle cDNA libraries that contain only the 300-500 bp long 3’-portions of muscle transcripts. Protocol: 2688 different cDNA inserts were PCR amplified directly from bacterial cultures. more...

Organism:

Homo sapiens

1 DataSet

2 Series

16 Samples

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(Submitter supplied) Temporal expression profiling of hindlimb muscle of beta- and gamma-sarcoglycan deficient mice aged 1, 2.5, 4, 6, 8, 10, 12, 14 and 20 weeks. Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1770

36 Samples

Download data

(Submitter supplied) Time-course microarray data set of mdx and wild type mice ranging from 1-20 weeks of age Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL485

36 Samples

Download data

(Submitter supplied) To test the hypothesis that different muscles may express variable amounts of different isoforms of muscle genes, we applied a custom-designed exon microarray containing probes for 57 muscle-specific genes to assay the transcriptional profiles in sets of human adult, lower limb skeletal muscles.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20574

137 Samples

Download data: GPR, TXT, XLS