GEO DataSets

(Submitter supplied) Two isocaloric, isonitrogenous diets containing 10% (w/w) olive oil or unsaponifiable-enriched olive oil have been provided to male apo E knockout mice for 11 weeks. Then RNA was isolated and hepatic gene expression analyzed. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

2 Samples

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(Submitter supplied) Two olive oils only differing in the presence of maslinic acid were prepared. Using DNA microarrays, hepatic gene expression was analysed in apoE-deficient mice with a C57BL/6J genetic background Keywords: diet study

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

2 Samples

Download data: CEL

(Submitter supplied) The hypothesis that the oleanolic acid of olive oil might influence hepatic gene expression in an apoE was tested in mice. Gene expression was analyzed using DNA microarrays in male apoE-deficient mice that received 10 mg/kg/day of oleanolic acid for 11 weeks.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

2 Samples

Download data: CEL

(Submitter supplied) apoE-deficient mice were fed a Western-type diet enriched with linoleic acid (control), cis-9, trans-11-CLA or trans-10, cis-12-CLA (1.0 % wt/wt) for 12 weeks and their hepatic gene expression was analysed using DNA microarrays Keywords: influence of diet

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

3 Samples

Download data: CEL

(Submitter supplied) Exposure to high levels of arsenic in drinking water is associated with several types of cancers including lung, bladder and skin, as well as vascular disease and diabetes. Drinking water standards are based primarily on epidemiology and extrapolation from higher dose experiments, rather than measurements of phenotypic changes associated with chronic exposure to levels of arsenic similar to the current standard of 10ppb, and little is known about the difference between arsenic in food as opposed to arsenic in water. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

59 Samples

Download data: CEL, CHP

(Submitter supplied) We examined the effects of high-fat diet on feeding behaviour, body weight regulation and common biomarkers associated with weight gain in the C57BL/6J mice over a period of 10 weeks, making measurements at weeks 2, 4 and 10. We examined the transcriptomic profile of hepatic genes involved in the major lipid metabolic pathways, validating the key genes with quantitative real-time reverse-transcription PCR (qRT-PCR) and their gene products with western blots. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL1261 GPL339

6 Samples

Download data: CEL

(Submitter supplied) Olive oil is protective against risk factors for cardiovascular and cancer diseases. A nutrigenomic approach was performed to assess whether olive oil, the main fat of the Mediterranean diet modifies the gene expression in human peripheral blood mononuclear cells. Six healthy male volunteers ingested, at fasting state, 50 ml of olive oil, and continued with the same olive oil as a source of raw fat (25ml/day) during 3 weeks. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3691

Platform:

GPL6511

9 Samples

Download data: TXT

(Submitter supplied) see manufacturer's web site https://products.appliedbiosystems.com/ab/en/US/adirect/ab;jsessionid=HyNBrYvlwy6ncF1Kn3KVLSLwlbXWyxZLRyZJthLvtFdht7vG2L2T!161467451?cmd=catProductDetail&productID=4359030&catID=602388&backButton=true

Organism:

Homo sapiens

1 DataSet

1 Series

9 Samples

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Analysis of PBMCs from healthy males after 3 weeks of virgin olive oil (VOO) consumption at doses common in the Mediterranean diet. The Mediterranean diet protects against cardiovascular diseases. Results provide insight into the molecular mechanisms underlying the beneficial action of VOO.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol, 3 time sets

Platform:

GPL6511

Series:

GSE10590

9 Samples

Download data: TXT

(Submitter supplied) The acute response four hours after a fat load of extra virgin olive oil was investigated using DNA microarrays. Hepatic gene expression was analysed in Wistar Rats.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

2 Samples

Download data: CEL

(Submitter supplied) Background and Purpose: Squalene is the main hydrocarbon present in extra virgin olive oil and it has been reported to have anti-steatotic properties in different animal models. The aims of this study were to investigate its effects on liver transcriptomics in Male C57BL/6J Apoe-deficient mice. Experimental Approaches: Male C57BL/6J Apoe-deficient mice were fed a purified Western diet with or without squalene during 11 weeks and hepatic squalene content was assessed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

6 Samples

Download data: TXT

(Submitter supplied) Purpose: The goal of this study was to determine erythrodiol effect on hepatic transcriptome by comparing high-throughput data for tested group vs. control group. Method: Hepatic mRNA profile of two Apoe deficient male mice groups fed over 12 weeks with either western diet or same diet enriched with 10 mg/kg erythrodiol was analysed by Transcriptome sequencing using BGISEQ-500 platform. Sequence reads that passed quality filters were mapped onto reference genome, followed by novel gene prediction, SNP & INDEL calling and gene-splicing detection. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23479

14 Samples

Download data: FA, GTF, TXT, VCF, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6422

41 Samples

Download data

(Submitter supplied) OPP (1500 ppm gallic acid equivalent (GAE)) was supplemented to BALB/c mice given an atherogenic diet for six weeks to observe for possible anti-atherogenic effects. The control group received distilled water instead of OPP. Livers, spleens and hearts were harvested six weeks after the feeding regimen for gene expression studies. Results from the separate microarray data analysis carried out on the different organs show that OPP attenuated the effects of the atherogenic diet in the organs.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6422

19 Samples

Download data: TXT

(Submitter supplied) BALB/c mice were given an atherogenic diet and compared to those given a normal diet to observe for gene expression changes caused by the atherogenic diet. Both groups of mice received distilled water as drinks ad libitum. Livers, spleens and hearts were harvested six weeks after the feeding regimen for gene expression studies. Results from the separate microarray data analysis carried out on the different organs show that the atherogenic diet caused oxidative stress and inflammation in the organs.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6422

22 Samples

Download data: TXT

(Submitter supplied) OPP (1500 ppm gallic acid equivalent (GAE)) was supplemented to BALB/c mice given a normal diet to observe for possible neuroprotective effects. Brains were harvested six weeks after the feeding regimen for gene expression studies. Results from the separate microarray data analysis carried out on the different organs show that OPP have neuroprotective properties in vivo.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6422

6 Samples

Download data: TXT

(Submitter supplied) OPP (1500 ppm gallic acid equivalent (GAE)) was supplemented to BALB/c mice inoculated subcutaneously with J558 myeloma cells at the dorsum of the neck in order to observe possible immune responses in cancer suppression. Spleens and livers were harvested at three designated time points, eighteen hours, one week and four weeks after inoculation of the cells for gene expression studies. Results show that the expression of immune-related genes in the spleen was delayed, while those related to inflammation in the liver were down-regulated across time, thus suggesting that OPP may have anti-inflammatory properties in suppressing cancer.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6422

36 Samples

Download data: TXT