GEO DataSets

(Submitter supplied) Summary: Astrocytomas can be categorized as either low grade or high grade (glioblastoma). Low grade astrocytomas are not generally aggressive tumors whereas glioblastomas are and in turn have a high mortality rate. The purpose of this experiment is to identify genetic differences between the two types. Hypothesis: There will be a difference in RNA expression between high grade and low grade tumors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2853

Platforms:

GPL8300 GPL96

20 Samples

Download data: CEL

Comparison of low and high grade astrocytoma brain tumors. Results provide insight into the molecular differences between the two types of tumors.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state, 2 other sets

Platform:

GPL8300

Series:

GSE3185

16 Samples

Download data: CEL

(Submitter supplied) Cell lines. HEK293 human embryonic kidney cells were obtained from ATCC (American Type Culture Collection, Manassas, VA) and were maintained in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum (Heat inactivated, Hyclone, Logan, Utah) and 1X antibiotics/glutamine (100 units/ml penicillin, 100ug/ml streptomycin, 292ug/ml L-Glutamine sulfate, all from Invitrogen Corp, Carlsbad, CA.), under either hypoxic (1% O2) or normoxic (21% O2) conditions at 37C in a tissue culture incubator. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2018

Platform:

GPL1528

10 Samples

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Analysis of HEK293T embryonic kidney cells subjected to hypoxia or overexpressing hypoxia-inducible factor (HIF)-1, degradation resistant HIF-1, or HIF-2. Results provide insight into the respective roles of HIF-1 and HIF-2 in the cellular response to hypoxia.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 4 protocol sets

Platform:

GPL1528

Series:

GSE2020

10 Samples

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(Submitter supplied) Gene expression profiles of 39 human sarcoma samples (GSM 52571-GSM52609) and 15 control samples (GSM52556-GSM52570) were assessed using Affymetrix HG U133A oligonucleotide arrays. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1209

Platform:

GPL96

54 Samples

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Expression profiling of soft tissue sarcoma samples. Hypoxic regions often develop in tumors as they increase in size. Results provide insight into the expression of hypoxia-related genes in sarcomas.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 23 tissue sets

Platform:

GPL96

Series:

GSE2719

54 Samples

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(Submitter supplied) Whole-genome screening of DNA-copy number changes by array-based or matrix comparative genomic hybridization (matrix-CGH). Keywords: Repeat sample.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL2920

68 Samples

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(Submitter supplied) Whole-genome BAC-array. Isolated BAC-DNA was amplified by two-step DOP-PCR. PCR products were dissolved in 3xSSC, 1.5M betaine and spotted as triplicates on epoxysilane-coated slides.

Organism:

Homo sapiens

1 Series

68 Samples

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(Submitter supplied) Malignant glioma is the most common type of primary brain tumor diagnosed annually in 16,000 individuals in the United States. We performed a systematic large-scale transcriptomics data mining study of 9,783 Affymetrix samples from the GeneSapiens database in order to identify those genes that are most glioma-specific as compared to other cancers and normal tissues. We searched for genes that are highly expressed in 322 glioblastoma multiforme tissue samples and 66 anaplastic astrocytomas as compared to 425 samples from histologically normal central nervous system. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

20 Samples

Download data: TXT

(Submitter supplied) Pilocytic astrocytoma (PA) is a low-grade neoplasm frequently found in childhood. PA is characterized by slow growth and a relatively good prognosis. Genetic mechanisms such as activation of MAPK, BRAF gene deregulation and neurofibromatosis type 1 (NF1) syndrome have been associated with PA development. Epigenetic signature and miRNA expression profile are providing new insights about different types of tumor, including PAs. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL20906

28 Samples

Download data: TXT

(Submitter supplied) Juvenile pilocytic astrocytoma (JPA) is one of the most common brain tumors in children. The expression profiles of 21 JPAs, determined using Affymetrix GeneChip U133A, were compared with subjects with normal cerebella. The genes involved in neurogenesis, cell adhesion, synaptic transmission, central nervous system development, potassium ion transport, protein dephosphorylation, and cell differentiation were found to be significantly deregulated in JPA. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

25 Samples

Download data: CEL, CHP

(Submitter supplied) Survival in the majority of high grade astrocytoma (HGA) patients is very poor, with only a rare population of long-term survivors. A better understanding of the biological factors associated with long-term survival in HGA would aid development of more effective therapy and prognostication. We used microarray gene expression profiling of 26 patient surgical samples with known clinical outcomes to discover novel prognostic markers.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4465

Platform:

GPL570

26 Samples

Download data: CEL

Analysis of surgical brain tumors from high grade astrocytoma (HGA) patients with known clinical outcomes. Increased expression of immune function-related genes was positively correlated with longer survival. Results provide insight into molecular profiles associated with long-term survival in HGA.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 21 time sets

Platform:

GPL570

Series:

GSE33331

26 Samples

Download data: CEL