GEO DataSets

(Submitter supplied) Chick pinealocytes exhibit all the characteristics of a complete circadian system, comprising photoreceptive inputs, molecular clockworks and an easily measured rhythmic output, melatonin biosynthesis. We used microarray analysis to investigate the expression of approximately 8000 genes within cultured pinealocytes subjected to both LD and DD cycles. We report that a reduced subset of genes were rhythmically expressed in vitro compared to those previously published in vivo, and that gene expression rhythms were lower in amplitude, although the functional distribution of the rhythmic transcriptome was largely similar. more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL3731

196 Samples

Download data

(Submitter supplied) Microarray data allowed detection of genes that have circadian expression pattern in the zebrafish pineal gland

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

12 Samples

Download data: CEL

(Submitter supplied) Homeobox genes generally encode transcription factors involved in regulating developmental processes. In the pineal gland, a brain structure devoted to nocturnal melatonin synthesis, a number of homeobox genes are also expressed postnatally; among these are the LIM homeobox 4 gene (Lhx4) and the brain‐specific homeobox gene (Bsx). As part of a larger study, we used of siRNA technology to knock down Lhx4 or Bsx expression in cultured adult rat pinealocytes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

9 Samples

Download data: XLSX

(Submitter supplied) The vertebrate pineal gland is dedicated to the production of the hormone melatonin, which increases at night to influence circadian and seasonal rhythms. This increase is associated with dramatic changes in the pineal transcriptome. Here, single-cell analysis of the rat pineal transcriptome was approached by sequencing mRNA from ~17,000 individual pineal cells, with the goals of profiling the cells that comprise the pineal gland and examining the proposal that there are two distinct populations of pinealocytes differentiated by the expression of Asmt, which encodes the enzyme that converts N-acetylserotonin to melatonin. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

10 Samples

Download data: GTF, MTX, TSV, TXT

(Submitter supplied) The zebrafish pineal gland (epiphysis) is an autonomous clock organ. In addition to being a site of melatonin production, it contains photoreceptor cells and functions as a circadian clock pace maker, making zebrafish a useful model system to study the developmental control of expression of genes associated with melatonin synthesis and photodetection, and the circadian clock. Here we have used DNA microarray technology to study the zebrafish pineal transcriptome. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS3824

Platform:

GPL1319

69 Samples

Download data: CEL

Analysis of pineal gland across 5 developmental stages (3 larval, 2 adult) during the day and night. Pineal gland is a site of melatonin production, contains photoreceptor cells, and acts as a circadian clock pace maker. Results provide insight into the molecular basis of pineal gland development.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 5 age, 2 development stage, 2 time, 2 tissue sets

Platform:

GPL1319

Series:

GSE13371

69 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1355 GPL341 GPL85

50 Samples

Download data: CEL

(Submitter supplied) Biological processes are optimized by circadian and circannual biological timing systems. In vertebrates, the pineal gland plays an essential role in these systems by converting time into a hormonal signal, melatonin; in all vertebrates, circulating melatonin is elevated at night, independent of lifestyle. At night, sympathetic input to the pineal gland, originating from the circadian clock in the suprachiasmatic nucleus, releases norepinephrine. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS3701 GDS3702

Platform:

GPL1355

32 Samples

Download data: CEL

(Submitter supplied) Biological processes are optimized by circadian and circannual biological timing systems. In vertebrates, the pineal gland plays an essential role in these systems by converting time into a hormonal signal, melatonin; in all vertebrates, circulating melatonin is elevated at night, independent of lifestyle. We have analyzed the rat pineal transcriptome at mid-day and mid-night to identify genes that exhibit night/day changes in expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3700

Platform:

GPL341

12 Samples

Download data: CEL

(Submitter supplied) Biological processes are optimized by circadian and circannual biological timing systems. In vertebrates, the pineal gland plays an essential role in these systems by converting time into a hormonal signal, melatonin; in all vertebrates, circulating melatonin is elevated at night, independent of lifestyle. We have analyzed the rat pineal transcriptome at mid-day and mid-night to identify genes that exhibit night/day changes in expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3699

Platform:

GPL85

6 Samples

Download data: CEL

Analysis of pineal organ cultures treated with norepinephrine (NE) and cAMP. Effects of forskolin also examined. Previous studies of night/day differentially expressed genes suggest control by NE/cAMP signaling. Results of this study expand the scope of the NE/cAMP regulatory cascade.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL1355

Series:

GSE12343

12 Samples

Download data: CEL

Analysis of pineal glands and other tissues (retina, neocortex, cerebellum, hypothalamus, heart, and liver) obtained from Sprague-Dawley rats at mid-day (ZT7) or midnight (ZT19). Results provide insight into genes that characterize the pineal gland, independent of tonic or night/day influences.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 time, 7 tissue sets

Platform:

GPL1355

Series:

GSE12343

20 Samples

Download data: CEL

Analysis of pineal glands from Sprague-Dawley rats at mid-day (ZT7) or midnight (ZT19). Similar samples from pineal gland-specific DNF2 transgenic rats also examined. The pineal plays a vital role in vertebrate chronobiology. Results provide insight into night/day changes in pineal gene expression.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 time sets

Platform:

GPL341

Series:

GSE12342

12 Samples

Download data: CEL

Analysis of pineal glands from Sprague-Dawley rats at mid-day (Zeitgeber time ZT7) or midnight (ZT19). Rats were kept on a 14:10 light-dark (LD) cycle. The pineal gland plays a vital role in vertebrate chronobiology. Results provide insight into night/day changes in pineal gene expression.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 time sets

Platform:

GPL85

Series:

GSE12341

6 Samples

Download data: CEL

(Submitter supplied) Microarray data allowed detection of genes that are induced by light in the zebrafish pineal gland

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

12 Samples

Download data: CEL

(Submitter supplied) The cone-rod homeobox gene (Crx) encodes Crx, a transcription factor selectively expressed in two cell types, retinal photoreceptors and the melatonin secreting pinealocytes of the pineal gland. In this report the role of Crx in regulating gene expression in the mammalian pineal gland was extended using Affymetrix GeneChip technology. Deletion of Crx results in broad modulation of the mouse pineal transcriptome, including a >2-fold downregulation of 543 genes and a >2-fold upregulation of 745 genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL, TXT

(Submitter supplied) Light has a strong effect on whole organism physiology, such as the circadian rhythms that are phase delayed and advanced by light given at early and late subjective night, respectively. Despite the importance of the phase-dependent light responses, little is known about the underlying molecular mechanism. We performed a comprehensive analysis of genes induced by light in a phase-dependent manner in the chicken pineal gland, an organ that represents a unique vertebrate clock system harboring intrinsic light sensitivity.

Organism:

Gallus gallus

Type:

Expression profiling by array

Dataset:

GDS3857

Platform:

GPL3213

12 Samples

Download data: CEL, CHP

Analysis of pineal gland from 12-h light/12-h dark cycle-entrained chicks transferred to constant darkness, then exposed to a 1-hr light pulse at various time points (circadian time 6, CT14, CT22). Results provide insight into molecular mechanisms underlying time-of-day-dependent responses to light.

Organism:

Gallus gallus

Type:

Expression profiling by array, count, 2 protocol, 3 time sets

Platform:

GPL3213

Series:

GSE21915

12 Samples

Download data: CEL, CHP

(Submitter supplied) Circadian rhythms are oscillations with a periodicity of 24 hours that are controlled by an endogenous clock and are observed in virtually all aspects of mammalian function from expression of genes to complex physiological processes. The master clock is present in the suprachiasmatic nucleus (SCN) in the anterior part of the hypothalamus and controls peripheral clocks present in other parts of the body . more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

54 Samples

Download data: CEL, CHP

(Submitter supplied) In intact animals, time of drug administration may be an important factor influencing drug response. Our general goal seeks to incorporate circadian time into the study of corticosteroid regulated gene expression. This study is designed to examine fluctuations in gene expression in skeletal muscle within the 24 hour circadian cycle in normal animals. Circadian time is relevant to designing optimal corticosteroid dosing regimens. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3083

Platform:

GPL341

54 Samples

Download data: CEL