GEO DataSets

(Submitter supplied) In this study we have identified the target genes of SREBP1a and SREBP1c in primary cultures of human skeletal muscle cells using adenoviral vectors expressing the mature nuclear form of human SREBP1a or SREBP1c combined with oligonucleotide microarrays. Keywords: comparison of human myotubes infected either by SREBP1a or 1C

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1456

6 Samples

Download data: GPR

(Submitter supplied) In this study we have identified the target genes of BHLHB2 and BHLHB3 in primary cultures of human skeletal muscle cells using adenoviral vectors expressing either BHLHB2 or BHLHB3, and oligonucleotide microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1456

8 Samples

Download data: GPR

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) computational analysis of transcriptomic information during erythroid development Keywords: erythroid differentiation

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2431

Platform:

GPL570

18 Samples

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Analysis of adult differentiating CD34+ hematopoietic progenitor cells at various time points up to 11 days of growth in serum-free medium containing erythropoietin, interleukin-3 and stem cell factor. Results provide insight into the molecular basis of erythropoiesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 time sets

Platform:

GPL570

Series:

GSE4655

18 Samples

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(Submitter supplied) Aging of skeletal muscle tissue is characterized by loss of metabolic and contractile competence. It is thought that this phenomenon is driven via extrinsic and intrinsic factors. In order to identify age-dependent changes intrinsic to the muscle cell, microarray transcriptional profiles and measurements of glucose metabolism were performed in primary cultured human myotubes at different time points over seven weeks. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS647

Platform:

GPL8300

7 Samples

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Examination of aging myotubes from a muscle biopsy incubated in glucose. Myotubes in 25 mM glucose at 2, 3, 4, 5, and 7 weeks, and in 10 mM glucose at 4 weeks examined in reference to 0 mM glucose control at 1 week.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 growth protocol, 6 time sets

Platform:

GPL8300

Series:

GSE1144

7 Samples

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(Submitter supplied) Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism with metabolic and neurologic crises. Liver shows the highest level of glycerol kinase (GK) activity in humans and mice. Absence of genotype-phenotype correlations in patients with GKD indicate the involvement of modifier genes, including other network partners. To understand the molecular pathogenesis of GKD, we performed microarray analysis on liver mRNA from neonatal glycerol kinase (Gyk) knockout (KO) and wild type (WT) mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1555

Platform:

GPL1261

8 Samples

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Expression profiling of livers of 4 male glycerol kinase knockout mutants. Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism with metabolic and neurologic crises. Results provide insight into the pathogenesis of GKD.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE3843

8 Samples

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(Submitter supplied) Although global analyses of transcription factor binding provide one view of potential transcriptional regulatory networks, regulation also occurs at levels distinct from transcription factor binding. Here, we use a genetic approach to identify targets of transcription factors in yeast and reconstruct a functional regulatory network. First, we profiled transcriptional responses in S. cerevisiae strains with individual deletions of 263 transcription factors. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL3588

269 Samples

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(Submitter supplied) Although HSF1 is known to play an important role in regulating the cellular response to proteotoxic stressors, little is known about the structure and function of the HSF1 signaling network under both stressed and unstressed conditions. In this study, we used a combination of chromatin immunoprecipitation (ChIP) microarray analysis and time course gene expression microarray analysis with and without siRNA-mediated inhibition of HSF1 comprehensively identify genes directly and indirectly regulated by HSF1 and examine the structure of the extended HSF1 signaling network. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1733

Platform:

GPL571

42 Samples

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Analysis of HSF1-depleted HeLa cells at various time points up to 24 hours following heat shock treatment at 43 degrees C. Heat shock transcription factor HSF1 silenced using RNA interference (siHSF1_1, siHSF1_2). Results provide insight into the structure and function of the HSF1 signaling network.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 2 protocol, 6 time sets

Platform:

GPL571

Series:

GSE3697

42 Samples

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(Submitter supplied) Microgravity has a dramatic impact on human physiology, illustrated in particular with skeletal muscle impairment. A thorough understanding of the mechanisms leading to loss of muscle mass and structural disorders is necessary for the definition of efficient clinical and spaceflight countermeasures. We investigated the effects of long-term bed rest on transcriptome of soleus (SOL) and vastus lateralis (VL) muscles in healthy women (BRC group, n=8), and the potential beneficial impact of protein supplementation (BRN group, n=8) and of a combined resistance and aerobic training (BRE group, n=8). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6398

170 Samples

Download data: GPR

(Submitter supplied) This experiment details the gene expression data from the small intestine from a set of parasite resistant and a set of parasite susceptible sheep. Keywords = parasite resistance Keywords: other

Organism:

Bos taurus; Ovis aries

Type:

Expression profiling by array

Platform:

GPL1434

16 Samples

Download data

(Submitter supplied) This is a custom commercial array designed by Affymetrix and the Harley McAdams and Lucy Shapiro Labs at Stanford University using the Caulobacter crescentus strain CB15 genome annotation of 2001 (Proc Natl Acad Sci USA. 98:4136-4141). The construction of this Affymetrix GeneChip has been described by McGrath et. al., 2007. Nat Biotechnol. 25:584-592.

Organism:

Caulobacter vibrioides

4 Series

1 Related Platform

18 Samples

Download data: CDF

(Submitter supplied) This is a custom commercial array designed by Affymetrix and the Harley McAdams and Lucy Shapiro Labs at Stanford University using the Caulobacter crescentus strain CB15 genome annotation of 2001 (Proc Natl Acad Sci USA. 98:4136-4141). The construction of this Affymetrix GeneChip has been described by McGrath et. al., 2007. Nat Biotechnol. 25:584-592.

Organism:

Caulobacter vibrioides

4 Series

1 Related Platform

18 Samples

Download data: 1LQ

(Submitter supplied) In order to determine molecular rules for transcriptional regulation of targeted genes to explain in part the pleiotropic effect observed in animals and humans upon exposure to Aroclor 1254 we treated human hepatocytes with Aroclor1254 and analysed RNA expression using a Nimblegene human custom array. Keywords: Human hepatocytes, Aroclor1254 treatment, 20µM, 72h

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3872

2 Samples

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(Submitter supplied) 6 lean humans were submitted to a 3 hours hyperinsulinemic-euglycemic clamp. Skeletal muscle biopsies were taken before and after the clamp. Set of arrays that are part of repeated experiments

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6991

6 Samples

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(Submitter supplied) 3H-1, 2-dithiole-3-thione (D3T), an inducer of antioxidant and phase 2 genes, is known to enhance the detoxification of environmental carcinogens, prevent neoplasia, and to elicit other protective effects. However, a comprehensive view of the regulatory pathways induced by this compound has not yet been elaborated. Fischer F344 rats were gavaged daily for 5 days with vehicle or D3T (0.3 mmol/kg). The global changes of gene expression in liver were measured with Affymetrix RG-U34A chips. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1484

Platform:

GPL85

8 Samples

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