GEO DataSets

(Submitter supplied) The human cytomegalovirus (HCMV) encodes the chemokine receptor US28 that exhibits constitutive activity. NIH-3T3 cells stably transfected with US28 present a pro-angiogenic and transformed phenotype both in vitro and in vivo. We used gene expression profiling to determine how US28 constitutive activity modulates expression of genes compared to mock-transfected cells. Keywords: Comparison of stably transfected cell lines

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3547

Platform:

GPL1261

4 Samples

Download data: CEL

Analysis of fibroblast NIH-3T3 cells expressing the human cytomegalovirus (HCMV) chemokine receptor U28. HCMV proteins are present in malignancies such as colon cancer. U28 activates inflammatory and proliferative signaling pathways. Results provide insight into the role of U28 in oncogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL1261

Series:

GSE13567

4 Samples

Download data: CEL

(Submitter supplied) Tumor hypoxia is not a stable phenomenon but cycles between periods of deep hypoxia and reoxygenation. Cyclic hypoxia originates from heterogeneities in red blood cell flux and from the permanent remodelling of the angiogenic vascular network. Endothelial cells lining tumor blood vessels are therefore also influenced by cyclic hypoxia. The gene expression pattern promoted by cyclic hypoxia differs from those observed under normoxia and even continuous hypoxia. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

6 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) This study attemps to study the global effects of Serum Amyloid A (SAA) on human endothelial gene expression profile in different time points. Keywords: time course

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2471

Platform:

GPL570

8 Samples

Download data: CEL, EXP

Analysis of umbilical vein endothelial (HUVEC) cells stimulated with serum amyloid A (SAA) for up to 48 hours. SAA is an acute phase protein.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 time sets

Platform:

GPL570

Series:

GSE6241

8 Samples

Download data: CEL, EXP

(Submitter supplied) We used microarrays to compare the gene transcription level between HUVEC-kGPCR and HUVEC-vector stable cells. The goal is to identify the genes that are affected by KSHV kGPCR expression. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

2 Samples

Download data: CEL, CHP

(Submitter supplied) Glioblastoma multiforme (GBM) is a highly malignant primary central nervous neoplasm characterized by tumor cell invasion, robust angiogenesis, and a mean survival of 15 months. Human cytomegalovirus (HCMV) infection is present in > 90% of GBMs, although the role the virus plays in GBM pathogenesis is unclear. We report here that a majority of human GBM tumors express HCMV pp71, which has previously been found to promote cell cycle progression and viral replication, and that pp71 is expressed preferentially within the CD133+ cancer stem cell-like subpopulation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

2 Samples

Download data: CEL

(Submitter supplied) Human fibroblast monolayers plated at a density of 3 x 104 cells/cm2 in 850 cm2 roller bottles were infected at confluency (day 5 post-seeding) with purified virions of human cytomegalovirus (CMV) strain AD169varATCC (AD) or the AD169 US27/US28 deletion mutant virus RV101 (RV) at a multiplicity of infection of 10. After virus adsorption for 1h at 37C with 5% CO2, the inoculum was removed and the cells were washed twice with culture medium prior to the addition of fresh medium. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1530

Platform:

GPL2779

12 Samples

Download data

Analysis of fibroblasts infected with cytomegalovirus (CMV) AD169 strain or a derivative lacking the CMV chemokine receptor US28. Cells examined at 50, 72, and 98 hours post-infection. Results identify pathways affected by CMV and provide insight into the role of US28 in the late phase of infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 infection, 3 time sets

Platform:

GPL2779

Series:

GSE3194

12 Samples

Download data