GEO DataSets

(Submitter supplied) Background Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by joint destruction and perpetuated by the synovial membrane (SM). In the inflamed SM, activated synovial fibroblasts (SFB) form the major cell type promoting development and progression of the disease by an abnormal expression/secretion of pro-inflammatory cytokines, tissue-degrading enzymes resulting in a predominant degradation of the extra-cellular matrix (ECM), and collagens causing joint fibrosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

60 Samples

Download data: CEL, CHP

(Submitter supplied) Synovial fibroblasts of 6 RA patients were treated with IL1 or PDGF-D. The aim of this study was to outline mechanism of the disease RA by a treatment with one of these cytokines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15445

60 Samples

Download data: CEL

(Submitter supplied) mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Keywords: disease type comparison, mRNA expression study

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2931

Platform:

GPL8300

12 Samples

Download data: CEL, CHP

Comparison of synovial fibroblasts from patients with rheumatoid arthritis (RA) to those with osteoarthritis (OA). RA is characterized by chronic inflammation and destruction of multiple joints. OA is a degenerative disease resulting from the breakdown of cartilage.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 other sets

Platform:

GPL8300

Series:

GSE7669

12 Samples

Download data: CEL, CHP

(Submitter supplied) The aim of this study was to compare gene expression between two pathological groups of human synovial fibroblasts (SF) from rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissues with normal SF from healthy individuals (HSF). We used microarray expression profiling in SF cultured from OA, RA and normal synovial tissues. We found larger numbers of transcripts with differential expression in OASF compared to the other groups than in RASF compared to HSF. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

31 Samples

Download data: TXT

(Submitter supplied) Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory/degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discrimination by employing a novel unbiased approach using rule-based classifiers. Three multi-center genome-wide transcriptomic data sets (Affymetrix HG- U133 A/B) from a total of 79 individuals, including 20 healthy controls (control group - CG), as well as 26 osteoarthritis (OA) and 33 RA patients, were used to infer rule- based classifiers to discriminate the disease groups. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5402

Platform:

GPL96

16 Samples

Download data: CEL

(Submitter supplied) Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory/degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discrimination by employing a novel unbiased approach using rule-based classifiers. Three multi-center genome-wide transcriptomic data sets (Affymetrix HG- U133 A/B) from a total of 79 individuals, including 20 healthy controls (control group - CG), as well as 26 osteoarthritis (OA) and 33 RA patients, were used to infer rule- based classifiers to discriminate the disease groups. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5403

Platform:

GPL96

33 Samples

Download data: CEL

(Submitter supplied) Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory/degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discrimination by employing a novel unbiased approach using rule-based classifiers. Three multi-center genome-wide transcriptomic data sets (Affymetrix HG- U133 A/B) from a total of 79 individuals, including 20 healthy controls (control group - CG), as well as 26 osteoarthritis (OA) and 33 RA patients, were used to infer rule- based classifiers to discriminate the disease groups. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5401

Platform:

GPL96

30 Samples

Download data: CEL

Analysis of synovial tissues from patients with rheumatoid arthritis or osteoarthritis. Results used to generate rule-based classifiers to distinguish patients with rheumatoid arthritis from those with osteoarthritis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL96

Series:

GSE55457

33 Samples

Download data: CEL

Analysis of synovial tissues from patients with rheumatoid arthritis or osteoarthritis. Results used to generate rule-based classifiers to distinguish patients with rheumatoid arthritis from those with osteoarthritis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL96

Series:

GSE55584

16 Samples

Download data: CEL

Analysis of synovial tissues from patients with rheumatoid arthritis or osteoarthritis. Results used to generate rule-based classifiers to distinguish patients with rheumatoid arthritis from those with osteoarthritis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL96

Series:

GSE55235

30 Samples

Download data: CEL

(Submitter supplied) Background. Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease, characterized by overexpression of pro-inflammatory/-destructive genes and other activating genes (e.g., proto-oncogenes) in the synovial membrane (SM). The gene expression in disease is often characterized by significant inter-individual variances via specific synchronization/ desynchronization of gene expression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

57 Samples

Download data: CEL

(Submitter supplied) Objectives: Epigenetics can influence disease susceptibility and severity. While DNA methylation of individual genes has been explored in autoimmunity, no unbiased systematic analyses have been reported. Therefore, a genome-wide evaluation of DNA methylation loci in fibroblast-like synoviocytes (FLS) isolated from the site of disease in rheumatoid arthritis (RA) was performed. Methods: Genomic DNA was isolated from six RA and five osteoarthritis (OA) FLS lines and evaluated using the Illumina HumanMethylation450 chip. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL16304

11 Samples

Download data

(Submitter supplied) Gene expression profiling of BMMC from patients with rheumatoid arthritis (RA) vs. osteoarthritis (OA).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

19 Samples

Download data: CEL

(Submitter supplied) Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we investigated the global molecular effects of Tocilizumab, an approved humanized anti-IL6 Receptor antibody, versus Methotrexate therapy, in synovial biopsy samples collected prospectively in early RA before and 12 weeks after administration of the drug. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5068 GDS5069

Platform:

GPL570

40 Samples

Download data: CEL

(Submitter supplied) Rheumatoid arthritis (RA) is an inflammatory joint disorder that results in progressive joint damage when insufficiently treated. In order to prevent joint destruction and functional disability in RA, early diagnosis and initiation of appropriate treatment with Disease-Modifying Antirheumatic Drugs (DMARDs) is needed. However, in daily clinical practice, patients may initially display symptoms of arthritis that do not fulfil the classification criteria for a definite diagnosis of RA, or any other joint disease, a situation called “Undifferentiated Arthritis” (UA). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4195

Platform:

GPL570

25 Samples

Download data: CEL, CHP

(Submitter supplied) Objective: Rituximab displays therapeutic benefits in the treatment of rheumatoid arthritis (RA) patients resistant to TNF blockade. However, the precise role of B cells in the pathogenesis of RA is still unknown. In this study we investigated the global molecular effects of rituximab in synovial biopsies obtained from anti-TNF resistant RA patients before and after administration of the drug. Methods: Paired synovial biopsies were obtained from the affected knee of anti-TNF resistant RA patients before (T0) and 12 weeks after initiation of rituximab therapy (T12). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4903

Platform:

GPL570

24 Samples

Download data: CEL, CHP

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of methotrexate (MTX) therapy. Results compared to those obtained from tocilizumab (TCZ) therapy (GDS5068) and provide insight into the differences in the mechanisms of action between TCZ and MTX.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 8 individual sets

Platform:

GPL570

Series:

GSE45867

16 Samples

Download data: CEL

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of tocilizumab (TCZ) therapy. Results compared to those obtained from methotrexate (MTX) therapy (GDS5069) and provide insight into the differences in the mechanisms of action between TCZ and MTX.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 12 individual sets

Platform:

GPL570

Series:

GSE45867

24 Samples

Download data: CEL

Analysis of synovial biopsy samples from anti-TNF resistant rheumatoid arthritis (RA) patients 12 wks after the start of rituximab (RTX) therapy. RTX is a mAb against CD20, expressed on subsets of B cells. Results provide insight into how RTX-induced B cell depletion interferes with RA pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 12 individual sets

Platform:

GPL570

Series:

GSE24742

24 Samples

Download data: CEL, CHP