Similar studies for GEO DataSets (Select 200016680) - GEO DataSets

Select item 2000166801.

arrayCGH profiles of endometrial cancer with and without prior prolonged tamoxifen treatment for primary breast cancer

(Submitter supplied) Full title: comparison of the genomic (arrayCGH) profiles of endometrial cancer with and without prior prolonged tamoxifen treatment for primary breast cancer Purpose: Tamoxifen has been a very effective treatment for breast cancer for several decades, however, at the same time increases the risk of endometrial cancer, especially after prolonged exposure. In addition, tamoxifen has been associated with a higher proportion of unfavorable uterine tumor subtypes (carcinosarcomas and serous adenocarcinomas) with worse survival. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platform:: GPL4560
97 Samples

Download data: TXT

Series

Accession:: GSE16680

ID:: 200016680

Select item 2000337232.

Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis.

(Submitter supplied) The molecular events implicated in the development of endometrial carcinosarcoma remain poorly understood. Using complementary DNA microarrays, we analyzed a group of 15 endometrial carcinosarcomas and compared their gene expression profiles with those obtained from a group of 23 endometrioid endometrial carcinomas. We demonstrated changes in the expression of genes modulating processes such as the epithelial to mesenchymal transition, muscle differentiation, the expression of cancer/testis antigens, and immune response in endometrial carcinosarcomas. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL4133 GPL6848
38 Samples

Download data: TXT

Series

Accession:: GSE33723

ID:: 200033723

Select item 2000044053.

High-resolution gene copy number and expression profiling of human chromosome 22 in ovarian carcinomas

(Submitter supplied) This set contains the aCGH data for the publication. Previous low-resolution studies of chromosome 22 in ovarian carcinoma have suggested its involvement in the development of the disease. We report a high-resolution analysis of DNA copy number and gene expression of 22q in 18 ovarian carcinomas using a 22q-specific genomic microarray. We identified aberrations in 67% of the studied tumors, which displayed 3 distinct gene copy number profiles. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

5 related Platforms
15 Samples

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Series

Accession:: GSE4405

ID:: 200004405

Select item 2000812134.

Comparative cistromics reveals genomic crosstalk between FOXA1 and ERα in tamoxifen-associated endometrial carcinomas

(Submitter supplied) Tamoxifen, which is used to treat breast cancer, increases the risks of endometrial cancer. In this study, we performed a genome-wide assessment of ERα-chromatin interactions in surgical specimens obtained from patients with tamoxifen-associated endometrial cancer. ERα was found at active enhancers in endometrial cancer cells as marked by the presence of RNA polymerase II and the histone marker H3K27Ac. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
23 Samples

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Series

Accession:: GSE81213

ID:: 200081213

PubMed Similar studies SRA Run Selector

Select item 2000325075.

Expression profile of carcinosarcoma (CS), endometrioid adenocarcinoma (EC) and sarcoma (US) of uterine corpus

(Submitter supplied) To examine the simlarity of CS, EC and US, we performed microarray analysis of frozen tissues of 46 patients (14 CS, 24 EC and 8 US).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
46 Samples

Download data: TXT

Series

Accession:: GSE32507

ID:: 200032507

Select item 2000945246.

Tamoxifen-associated endometrial tumors expose differential enhancer activity for Estrogen Receptor alpha

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL3676 GPL11154
135 Samples

Download data: TXT

Series

Accession:: GSE94524

ID:: 200094524

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000945237.

Tamoxifen-associated endometrial tumors expose differential enhancer activity for Estrogen Receptor alpha [Microarray Expression]

(Submitter supplied) Tamoxifen, a small molecule inhibitor that binds the Estrogen Receptor alpha (ERα), blocks breast cancer progression while increasing the risk for endometrial cancer. In this study, we assessed genome-wide ERα-chromatin interactions in surgical specimens of endometrial tumors from patients who were previously treated for breast cancer with tamoxifen, and endometrial tumors from patients who were treated without tamoxifen. more...