GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Protein profiling by protein array

Platforms:

GPL9165 GPL9163

23 Samples

Download data: GPR

(Submitter supplied) Splenocytes harvested from mice with FIA were cultured in vitro and stimulated with 0.01 mg/ml fibrinogen for 3 days. Enriched T cells were transferred into 6-week-old naïve SJL mice, which developed visible signs of arthritis within 2 weeks. Synovial array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B cell responses against peptides representing native fibrinogen, and further spreading of the responses to target collagen type V, cartilage gp39, and citrullinated vimentin. more...

Organism:

Mus musculus; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL9165

9 Samples

Download data: GPR

(Submitter supplied) Plasma collected from mice with FIA were pooled, and 0.3 ml was injected intravenously into 6-week-old naïve SJL mice on days 0 and 2. Synovial antigen array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B-cell responses against peptides representing native fibrinogen and citrullinated fibrinogen, and further epitope spreading resulting in additional targeting of fibronectin, collagen type V, cartilage gp39, and clusterin.

Organism:

Mus musculus; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL9165

8 Samples

Download data: GPR

(Submitter supplied) Synovial antigen arrays were probed with 1:150 dilutions of plasma derived from SJL mice immunized with fibrinogen emulsified in CFA or with CFA alone. Autoantibody binding was detected with a Cy3-conjugated goat-anti-mouse IgG/M secondary antibody. SAM was applied to identify antigens with statistically significant differences in array reactivity between FIA and CFA control plasma (q < 0.01) obtained from mice before boosting. more...

Organism:

Mus musculus; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL9163

10 Samples

Download data: GPR