Similar studies for GEO DataSets (Select 200018700) - GEO DataSets

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Items: 20

Select item 2000187001.

Genome-wide DNA methylation profiling of Acute Myeloid Leukemia

(Submitter supplied) We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML subtypes that shared no other known feature. In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11 and PML-RARA leukemia entities are associated with specific methylation profiles. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL6604
352 Samples

Download data: PAIR

Series

Accession:: GSE18700

ID:: 200018700

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000144682.

Gene expression profiling of CEBPA double and single mutant and CEBPA wild type AML.

(Submitter supplied) Mutations in CCAAT/enhancer binding protein alpha (CEBPA) are seen in 5-14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations simultaneously carry two mutations (CEBPAdouble-mut), usually biallelic, while single heterozygous mutations (CEBPAsingle-mut) are less frequently seen. Using denaturing high performance liquid chromatography and nucleotide sequencing we identified among a cohort of 598 newly diagnosed AMLs a subset of 41 CEBPA mutant cases, i.e. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
526 Samples

Download data: CEL

Series

Accession:: GSE14468

ID:: 200014468

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000635693.

RNA sequencing of bone marrow CD34+ cells from myelodysplastic syndrome patients with and without SF3B1 mutation and from healthy controls

(Submitter supplied) The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ring sideroblasts (RARS). MDS is a disorder of the hematopoietic stem cell and we thus studied the transcriptome of CD34+ cells from MDS patients with SF3B1 mutations using RNA-sequencing. Genes significantly differentially expressed at the transcript and/or exon level in SF3B1 mutant compared to wildtype cases include genes involved in MDS pathogenesis (ASXL1, CBL), iron homeostasis and mitochondrial metabolism (ALAS2, ABCB7, SLC25A37) and RNA splicing/processing (PRPF8, HNRNPD). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
17 Samples

Download data: TXT

Series

Accession:: GSE63569

ID:: 200063569

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001954974.

EVI1 drives leukemogenesis through aberrant activation of ERG

(Submitter supplied) Chromosomal rearrangements involving EVI1 (MECOM) define a subtype of acute myeloid leukemia (AML) that is associated with a two-year survival rate of <10%. Gene regulatory functions of EVI1 are largely elusive and no targeted therapeutics exist. We developed experimentally tractable murine and human leukemia models that recapitulate phenotypic and transcriptional features of EVI1-rearranged AML and enable large-scale loss-of-function screens. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms
38 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE195497

ID:: 200195497

PubMed Similar studies

Select item 2000861515.

Targeting the Creatine Kinase Pathway in EVI1-Positive Acute Myeloid Leukemia

(Submitter supplied) Purpose: Identify new targets in EVI1-Positive Acute Myeloid Leukemia Methods: Treatment with cyclocreatine of EVI1-driven AML cell lines TF-1, UT-7 and UCSD-AML1. Cyclocreatine was purchased from Sigma-Aldrich (Sigma). TF-1, UT-7 and UCSD-AML1 cells were treated in quadruplicate with either vehicle or 3 mM cyclocreatine for 24 hours. Total RNA was extracted and profiled by RNA sequencing (HiSeq, Illumina) at BioMicroCenter from Massachusetts Institute of Technology (Cambridge, MA, USA). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: TXT

Series

Accession:: GSE86151

ID:: 200086151

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000601006.

EVI1 promotes tumor growth via transcriptional repression of MS4A3

(Submitter supplied) Background: The transcription factor EVI1 regulates cellular proliferation, differentiation, and apoptosis, and contributes to an aggressive course of disease in myeloid leukemias and other malignancies. Notwithstanding, knowledge about the target genes mediating its biological and pathological functions remains limited. We therefore aimed to identify and characterize novel EVI1 target genes in human myeloid cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
20 Samples

Download data: CEL

Series

Accession:: GSE60100

ID:: 200060100

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000666607.

Gene expression changes in U937 cells in response to ectopic expression of EVI1 and/or etoposide treatment

(Submitter supplied) Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid cell line constitutively overexpressing EVI1 after infection with a retroviral vector (U937_EVI1) was partially resistant to etoposide and daunorubicin as compared to empty vector infected control cells (U937_vec). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5809
Platform:: GPL11532
8 Samples

Download data: CEL

Series

Accession:: GSE66660

ID:: 200066660

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 58098.

Anti-leukemia drug etoposide effect on ecotropic viral integration site 1-overexpressing myeloid cells

Analysis of myeloid cell line U937 overexpressing ecotropic viral integration site 1 (EVI1) and cultured in the presence of antileukemic drug etoposide. Results provide insight into molecular mechanisms through which EVI1 confers resistance to drugs used in myeloid leukemia therapy.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 protocol sets

Platform:: GPL11532
Series:: GSE66660
8 Samples

Download data: CEL

DataSet

Accession:: GDS5809

ID:: 5809

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000422519.

Effects of EVI1 and EVI1Δ324 mild expression in HeLa cells

(Submitter supplied) We studied the variations of mRNA amounts after Flag-EVI1, Flag-EVI1Δ324, or Flag expression in HeLa cells. Despites EVI1 discovery in 1988, its recognized role as a dominant oncogene in myeloid leukemia and more recently in epithelial cancers, only a few target genes were known and it was not clear why EVI1 was involved in cancer progression. Here we obtained the genomic binding occupancy and expression data for EVI1 in human cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
12 Samples

Download data: CEL

Series

Accession:: GSE42251

ID:: 200042251

Select item 20006685410.

The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid [U937]

(Submitter supplied) The product of the ecotropic virus integration site 1 (EVI1) gene, whose overexpression is associated with a poor prognosis in myeloid leukemias and some epithelial tumors, regulates gene transcription both through direct DNA binding and through modulation of the activity of other sequence specific transcription factors. Previous results from our laboratory have shown that EVI1 influenced transcription regulation in response to the myeloid differentiation inducing agent, all-trans retinoic acid (ATRA), in a dual manner: it enhanced ATRA induced transcription of the RARb gene, but repressed the ATRA induction of the EVI1 gene itself. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5613
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE66854

ID:: 200066854

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006685311.

Transcriptional regulation by EVI1 in the absence or presence of TPA

(Submitter supplied) To investigate whether and how expression of the oncogenic transcription factor EVI1 influences gene regulation by phorbol esters and vice versa, the human myeloid cell line U937 was transduced with an EVI1 expression vector or empty vector as a control. Cells were treated with 12-Otetradecanoylphorbol 13-acetate (TPA) or its solvent ethanol as a control. RNA was extracted and subjected to gene expression microarray analysis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE66853

ID:: 200066853

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006683712.

The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid [HL60]

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5614
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE66837

ID:: 200066837

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 561413.

All-trans retinoic acid effect on HL60 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing HL60 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL570
Series:: GSE66837
12 Samples

Download data: CEL

DataSet

Accession:: GDS5614

ID:: 5614

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 561314.

All-trans retinoic acid effect on U937 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing U937 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL570
Series:: GSE66854
12 Samples

Download data: CEL

DataSet

Accession:: GDS5613

ID:: 5613

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20011492215.

RNA sequencing of bone marrow CD34+ hematopoietic stem and progenitor cells from patients with myelodysplastic syndrome and healthy controls

(Submitter supplied) SF3B1, SRSF2 and U2AF1 are the most frequently mutated splicing factor genes in MDS. We have performed a comprehensive analysis to determine the impact of these commonly mutated splicing factors on pre-mRNA splicing in the stem/progenitor cells and in the erythroid and myeloid precursors in splicing factor mutant MDS. Using RNA-seq, we determined the aberrantly spliced genes and dysregulated pathways in bone marrow CD34+ cells of a large group of 82 MDS patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
131 Samples

Download data: TXT

Series

Accession:: GSE114922

ID:: 200114922

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20020221116.

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia II

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL19057
10 Samples

Download data: BIGWIG

Series

Accession:: GSE202211

ID:: 200202211

PubMed Full text in PMC Similar studies

Select item 20020220817.

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia (RNA-Seq)

(Submitter supplied) Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 at MECOM drive inv(3)/t(3;3) myeloid leukemias and revealed MECOM germline mutations in patients with MECOM-associated bone marrow failure syndromes. Here we identify a novel, previously unannotated oncogenic RNA-splicing derived isoform of EVI1 which is frequently present in inv(3)/t(3;3) AML and directly contributes to leukemic transformation. more...