GEO DataSets

(Submitter supplied) We present here a new expression profiling study of the 60 cell lines of the National Cancer Institute (NCI) Developmental Therapeutics program (DTP) drug screen (NCI-60) using the 41,000-probe Agilent Whole Human Genome Oligo Microarray. The expression levels of ∼21,000 genes were measured.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6848

132 Samples

Download data: TXT

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4296

Platform:

GPL570

174 Samples

Download data: CEL

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5188

178 Samples

Download data: CEL

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

132 Samples

Download data: TXT

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel Keywords: cell_type_comparison_design; disease state; cell line; tissue type

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

300 Samples

Download data: CEL, EXP

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel Keywords: cell_type_comparison_design; disease state; cell line; tissue type

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

120 Samples

Download data: CEL

(Submitter supplied) Because most potential molecular markers and targets are proteins, proteomic profiling is expected to yield more direct answers to functional and pharmacological questions than does transcriptional profiling. To aid in such studies, we have developed a protocol for making reverse-phase protein lysate microarrays with larger numbers of spots than previously feasible. Our first application of these arrays was to profiling of the 60 human cancer cell lines (NCI-60) used by the National Cancer Institute to screen compounds for anticancer activity. more...

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL4081

176 Samples

Download data

Analysis of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, and Renal) from the NCI-60 panel. Results provide insight into molecular mechanisms underlying the various cancer types.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 59 cell line, 27 disease state, 9 tissue sets

Platform:

GPL570

Series:

GSE32474

174 Samples

Download data: CEL

(Submitter supplied) Murine hepatocellular carcinoma of similar size were collected from WT and Top1mt-/- livers. Total RNA was isolated from tumors of 3 mice for each genotype. We used RNA-seq to compare the genes differentially expressed between WT and Top1mt-/- murine HCC.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

6 Samples

Download data: TXT

(Submitter supplied) Methylation assay of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

61 Samples

Download data: IDAT, TXT

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

528 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

525 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

513 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

524 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

507 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

538 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

485 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

495 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

496 Samples

Download data: CEL

(Submitter supplied) To identify patterns of drug-induced gene modulation that occur across different cell types, we measured gene expression changes across NCI-60 cell lines after exposure to 15 anticancer agents. The results were integrated into a database and set of interactive analysis tools, the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), intended to allow exploration of gene expression modulation, including by molecular pathway, drug target, and association with drug sensitivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

536 Samples

Download data: CEL