Similar studies for GEO DataSets (Select 200024129) - GEO DataSets

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Items: 11

Select item 2000241291.

Gene expression profiling for placentas from pre-eclamptic, unexplained FGR and normal pregnancies.

(Submitter supplied) It has been well documented that pre-eclampsia and unexplained fetal growth restriction (FGR) has a common etiological background, but little is known about the linkage al the molecular level. we have performed global gene expression profiling by oligonucleotide microarrays for placentas from pre-eclamptic, unexplained FGR and normal pregnancies to further elucidate the mechanisms underlying the development of these two disorders.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
24 Samples

Download data: CEL

Series

Accession:: GSE24129

ID:: 200024129

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001004152.

Placental gene expression profiling for the identification of subtypes of human fetal growth restriction

(Submitter supplied) Fetal growth restriction (FGR) is a heterogeneous disorder of pregnancy associated with pathologically low fetal and neonatal weights. We hypothesized that FGR consists of multiple placental subtypes, similar to what we have observed in preeclampsia. To address this hypothesis, we assembled a fetal growth-focused human placental microarray data set (N=97) consisting of 20 new normotensive suspected FGR samples (below), in addition to term controls (N=26) and hypertensive suspected FGR samples (N=51) from GSE75010.

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis

Platform:: GPL6244
20 Samples

Download data: CEL, TXT

Series

Accession:: GSE100415

ID:: 200100415

PubMed Similar studies

Select item 2000750103.

Placental gene expression profiling for the identification of clinically relevant subclasses of human preeclampsia

(Submitter supplied) Preeclampsia (PE) is a complex, heterogeneous disorder of pregnancy, demonstrating considerable variability in observed maternal symptoms and fetal outcomes. We hypothesized that this heterogeneity is due to the existence of multiple molecular forms of PE. To address our hypothesis, we created a large (N=330) human placental microarray data set consisting of seven previously published studies (GSE30186, GSE10588, GSE24129, GSE25906, GSE43942, GSE4707, and GSE44711) and 157 highly annotated samples from a BioBank (below). more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis

Platform:: GPL6244
157 Samples

Download data: CEL, CSV

Series

Accession:: GSE75010

ID:: 200075010

PubMed Full text in PMC Similar studies

Select item 2000047074.

Microarray Analysis of Differentially Expressed Genes in Placental Tissue of Severe Preeclampsia

(Submitter supplied) Pre-eclampsia is one of the most serious pregnancy-associated disorders, and is defined by hypertension (systolic blood pressure higher than 140mmHg or diastolic blood pressure higher than 90mmHg) with proteinuria (more than 0.3g/day). It is not a simple complication of pregnancy, but is rather a syndrome of multiple organ failure involving the liver, kidney, and lung, as well as coagulatory and neural systems. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2080
Platform:: GPL1708
14 Samples

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Series

Accession:: GSE4707

ID:: 200004707

Select item 20805.

Early and late onset severe preeclampsia: placenta

Analysis of placentas from patients with early or late onset severe preeclampsia. Preeclampsia is a serious pregnancy-associated disorder characterized by hypertension and proteinuria. Results provide insight into the pathogenesis of preeclampsia.

Organism:: Homo sapiens

Type:: Expression profiling by array, log10 ratio, 3 disease state sets

Platform:: GPL1708
Series:: GSE4707
14 Samples

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DataSet

Accession:: GDS2080

ID:: 2080

Select item 2000447126.

Early-Onset Preeclampsia Placentas and Controls

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Expression profiling by array

Platforms:: GPL13534 GPL10558
56 Samples

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Series

Accession:: GSE44712

ID:: 200044712

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Select item 2000447117.

Gene expression in Early-Onset Preeclampsia Placentas and Controls

(Submitter supplied) We investigated the DNA methylation and gene expression of 20 chorionic villi samples from early onset preeclampsia placentas to 20 gestational age matched controls. From this we were able to see a widespread disregulation in DNA methylation across a subset of genes in the genome. This may help to elucidate the underlying biological problems that lead to early onset preeclampsia. We noted that there were DNA methylation changes in many genes of importance as well as in different genomic elements such as enhancers.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
16 Samples

Download data: TXT

Series

Accession:: GSE44711

ID:: 200044711

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000446678.

DNA methylation in Early Onset Preeclamptic placentas

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
40 Samples

Download data: TXT

Series

Accession:: GSE44667

ID:: 200044667

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002035079.

Molecular subphenotyping using placental transcriptomics in early-onset preeclampsia and fetal growth restriction

(Submitter supplied) Placental disorders contribute to pregnancy complications including preeclampsia (PE) and fetal growth restriction (FGR), but debate regarding their specific pathobiology persists. Our objective was to apply transcriptomics with weighted gene correlation network analysis (WGCNA) to further clarify the placental dysfunction in these conditions.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
57 Samples

Download data: TXT

Series

Accession:: GSE203507

ID:: 200203507

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Select item 20014777610.

Placental microarray profiling reveals common mRNA and lncRNA expression patterns in Preeclampsia and Intrauterine Growth Restriction

(Submitter supplied) Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are major contributor of perinatal morbility and mortality, these pregnancy disorders associated with placental ischemia and share many similar pathophysiological features. The aim of this study was to compare the placental gene expression profiles including mRNA and lnRNAs from pregnant women from four study groups; PE, IUGR, PE-IUGR and normal pregnancy (NP). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20844
28 Samples

Download data: TXT

Series

Accession:: GSE147776

ID:: 200147776

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010354211.

Dysregulated Placental Micrornas In Early And Late Onset Preeclampsia

(Submitter supplied) Introduction: To determine the miRNA expression profile in placentas complicated by Preeclampsia (PE) and compare it to uncomplicated pregnancies. Methods: Sixteen placentas from women with PE, including 11 with early onset PE (EOPE) and 5 with late onset PE (LOPE), as well as 8 from uncomplicated pregnancies were analyzed using miRNA microarrays. For statistical analyses the MATLAB® simulation environment was applied. more...