Similar studies for GEO DataSets (Select 200029682) - GEO DataSets

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Items: 20

Select item 2000296821.

Comparison between cell lines from 9 different cancer tissue (NCI-60) (Affymetrix HuEx 1.0)

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
178 Samples

Download data: CEL

Series

Accession:: GSE29682

ID:: 200029682

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Select item 2000324742.

Comparison between cell lines from 9 different cancer tissue (NCI-60) (Affymetrix U133 Plus 2.0)

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4296
Platform:: GPL570
174 Samples

Download data: CEL

Series

Accession:: GSE32474

ID:: 200032474

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Select item 2000292883.

Comparison between cell lines from 9 different cancer tissue (NCI-60) (Agilent WG platform)

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
132 Samples

Download data: TXT

Series

Accession:: GSE29288

ID:: 200029288

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Select item 2000228214.

NCI60 Expression Profiling using the Agilent Whole Human Genome Oligo Microarray

(Submitter supplied) We present here a new expression profiling study of the 60 cell lines of the National Cancer Institute (NCI) Developmental Therapeutics program (DTP) drug screen (NCI-60) using the 41,000-probe Agilent Whole Human Genome Oligo Microarray. The expression levels of ∼21,000 genes were measured.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6848
132 Samples

Download data: TXT

Series

Accession:: GSE22821

ID:: 200022821

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Select item 2000059495.

Comparison between cell lines from 9 different cancer tissue (NCI-60) (U95 platform)

Organism:: Homo sapiens

Type:: Expression profiling by array

5 related Platforms
300 Samples

Download data: CEL, EXP

Series

Accession:: GSE5949

ID:: 200005949

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Select item 2000057206.

Comparison between cell lines from 9 different cancer tissue (NCI-60) (U133 platform)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL97 GPL96
120 Samples

Download data: CEL

Series

Accession:: GSE5720

ID:: 200005720

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Select item 2000055017.

Comparison of protein expression profiles in NCI-60 cell panel containing nine difererent cancer tissue types.

(Submitter supplied) Because most potential molecular markers and targets are proteins, proteomic profiling is expected to yield more direct answers to functional and pharmacological questions than does transcriptional profiling. To aid in such studies, we have developed a protocol for making reverse-phase protein lysate microarrays with larger numbers of spots than previously feasible. Our first application of these arrays was to profiling of the 60 human cancer cell lines (NCI-60) used by the National Cancer Institute to screen compounds for anticancer activity. more...

Organism:: Homo sapiens

Type:: Protein profiling by protein array

Platform:: GPL4081
176 Samples

Download data

Series

Accession:: GSE5501

ID:: 200005501

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Select item 42968.

NCI-60 cancer cell line panel

Analysis of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, and Renal) from the NCI-60 panel. Results provide insight into molecular mechanisms underlying the various cancer types.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 59 cell line, 27 disease state, 9 tissue sets

Platform:: GPL570
Series:: GSE32474
174 Samples

Download data: CEL

DataSet

Accession:: GDS4296

ID:: 4296

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000791859.

The NCI-60 Methylome and Its Integration into CellMiner

(Submitter supplied) Methylation assay of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
61 Samples

Download data: IDAT, TXT

Series

Accession:: GSE79185

ID:: 200079185

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Select item 20000716110.

Non-Classical Functions of Human Topoisomerase I: Genome-wide and Pharmacological Analyses

(Submitter supplied) The biological functions of nuclear topoisomerase I (Top1) have been difficult to study because knocking out TOP1 is lethal in metazoans. To reveal the functions of human Top1, we have generated stable Top1siRNA cell lines from colon and breast carcinomas (HCT116-siTop1 and MCF-7-siTop1, respectively). In those cells, Top2 compensates for Top1 deficiency. A prominent feature of the siTop1 cells is genomic instability, with chromosomal aberrations and histone gamma-H2AX foci associated with replication. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE7161

ID:: 200007161

Select item 20018151311.

USP7 substrates identified by proteomics analysis reveal the specificity of USP7

(Submitter supplied) To check whether mRNA level change for the changed proteins in protein level.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
18 Samples

Download data: SF

Series

Accession:: GSE181513

ID:: 200181513

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Select item 20023969412.

G-quadruplex on Chromosomal DNA Negatively Regulates Topoisomerase 1 Activity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24676 GPL20795
13 Samples

Download data: BIGWIG

Series

Accession:: GSE239694

ID:: 200239694

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Select item 20023969213.

G-quadruplex on Chromosomal DNA Negatively Regulates Topoisomerase 1 Activity [ChIP-seq]

(Submitter supplied) Human DNA topoisomerase 1 (Top1) is a crucial enzyme responsible for alleviating torsional stress on DNA during transcription and replication, thereby maintaining genome stability. Previous researches had found that non-working Top1 interacted extensively with chromosomal DNA in human cells. However, the reason for its retention on chromosomal DNA remained unclear. In this study, we discovered a close association between Top1 and chromosomal DNA, specifically linked to the presence of G-quadruplex (G4) structures. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
4 Samples

Download data: BIGWIG

Series

Accession:: GSE239692

ID:: 200239692

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Select item 20023969014.

G-quadruplex on Chromosomal DNA Negatively Regulates Topoisomerase 1 Activity [CUT&Tag]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
9 Samples

Download data: BIGWIG

Series

Accession:: GSE239690

ID:: 200239690

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Select item 20014947815.

Effect of the USP7 inhibitor HBX41,108 on lipopolysaccharide induced gene expression in mouse bone marrow derived macrophages.

(Submitter supplied) USP7 is a deubiquitinase enzyme that removes polyubiquitin chains form a number of substrates including MDM2, p53 and NF-κB. In this study we assessed the impact of the USP7 inhibitor HBX41,108 on lipopolysaccharide (LPS) induded transcriptional responses in murine bone marrow derived macrophages.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
6 Samples

Download data: TXT

Series

Accession:: GSE149478

ID:: 200149478

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Select item 20002429516.

Gene expression in epithelial and non-epithelial cells of renal origin

(Submitter supplied) We aimed to define epithelial-specific genes in the kidney. In the developing mouse kidney at E12.5 epithelial cells are restricted to the ureteric bud, while mesenchymal cells surrounding the ureteric bud are non-epithelial. The mouse renal epithelial cell line mIMCD-3 was used to represent kidney epithelia in vitro. Gene expression was analyzed using Affymetrix microarrays in ureteric bud stalks, ureteric bud tips, and mIMCD-3 cells and compared to metanephric mesenchyme.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
7 Samples

Download data: CEL

Series

Accession:: GSE24295

ID:: 200024295

Select item 20007306017.

RNAseq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells

(Submitter supplied) The specialized corneal epithelium requires differentiated properties, specific for its role at the anterior surface of the eye, thus tight maintenance of the differentiated qualities of the corneal epithelial is essential. Our studies have focused on pinin (PNN), an exon junction component (EJC) that has dramatic implications on corneal epithelial cell differentiation and may act as a stabilizer of the corneal epithelial cell phenotype. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
32 Samples

Download data: XLSX

Series

Accession:: GSE73060

ID:: 200073060

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20006104818.

USP7 cooperates with SCML2 to regulate the activity of PRC1

(Submitter supplied) In this experiment, we sought to identify the distribution of USP7 on chromatin relative to other PRC1 components

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
1 Sample

Download data: BW

Series

Accession:: GSE61048

ID:: 200061048

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003735819.

Topoisomerase I cleavage complexes preferentially down-regulate ubiquitin- and RNA degradation-related transcripts in relationship to gene length, exon-intron junctions and p53-dependent up-regulation of miR-142-3p

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL15454 GPL10850
18 Samples

Download data: CEL, TXT

Series

Accession:: GSE37358

ID:: 200037358

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Select item 20003735220.

Transcription poisoning by topoisomerase I is controlled by gene length, splice sites and miR-142-3p

(Submitter supplied) DNA topoisomerase I (Top1) is required for transcription as it relaxes positive and negative supercoils by forming transient Top1 cleavage complexes (Top1cc) up- and down-stream of transcription complexes. However, Top1cc can also be trapped by endogenous DNA lesions and by camptothecin (CPT) and its anticancer derivatives, which results in transcription blocks. Here, we undertook a genome-wide analysis of the effects of CPT on gene expression at exon resolution.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15454
15 Samples

Download data: CEL, TXT

Series

Accession:: GSE37352

ID:: 200037352

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